Hercules Corporation

Wayne State University

Peng George Wang

Lei Qiao

Huai Nan Cheng

Wenhua Xie

Qu-Ming Gu

Dennis Murphy

Robert G Nickol

Xuejun Wu

Xiaoping Tang

Sugar-modified SIN-1 compositions are provided. The compositions are useful for generating NO in response to hydrolytic activity of a glycosidase specific for the O-glycosidic bond between the sugar and SIN-1 moieties. Pharmaceutical compositions containing the sugar-modified SIN-1 compositions and methods of using the compositions are also provided.

Enzyme activated nitric oxide donors

Polysaccharides comprising one or more oxime linkages are provided. Methods for their preparation include the polycondensation of saccharides bearing oxime-forming substituents. In some embodiments, polymerization is conducted in the presence of galactose oxidase. The resulting oxime-linked polysaccharides have desirable properties and are useful in numerous applications including paper manufacturing and drug delivery vehicles.

Oxime-linked polysaccharides and methods of preparing the same

A product of acetoacetylated saccharide and the process of making such a product. The process is enzymatic where an enzyme is used as a catalyst for the reaction. The enzymatic process provides better yields and milder process conditions compared to other chemical synthesis process without any enzyme.

Acetoacetylated saccharides and process of making the same

Growing community of inventors

Troy, MI, United States of America

Peng George Wang