Bristol-myers Squibb Compnay

Pharmacopeia Drug Discovery, Inc.

Peng Geng

Boguslaw Mudryk

Xinhua Qian

Jianji Wang

Kishta Katipally

Thomas M Razler

Carolyn S Wei

Ye Zhu

Steven R Wisniewski

Andrew Lee

Eric C Huang

Ronald Carrasquillo

Roland Ellwood Dolle

Koc-Kan Ho

Tao Guo

Edward McDonald

Kurt William Saionz

Guizhen Dong

Shawn K Pack

Michael J Smith

Steven G Kultgen

Ruiyan Liu

Junying Fan

Anton Egbert Peter Adang

Neil A Strotman

Nicole Corine Renee Van Straten

Alina Borovika

Dimitri Skliar

Jason Hamm

Jason Michael Stevens

Disclosed is a process for preparing Compound 8: comprising the step of reacting Compound of 7: wherein R is Calkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.

Process for preparing tetrahydrocarbazole carboxamide compound

Disclosed is a process for preparing (S)-4-(3-(but-2-ynamido)piperidin fluoro-2,3-dimethyl-1H-indole-7-carboxamide, comprising the steps of: preparing a compound of Formula (III); converting the compound of Formula (III) to a compound of Formula (V); and reacting the compound of Formula (V) with a compound of Formula (VI) to provide (S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide. 

Process for preparing indole carboxamide compounds

Disclosed is a process for preparing Compound 8: (8) comprising the step of reacting Compound of 7: (7) wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.

The present disclosure generally relates to a process for synthesizing methyl ((1S)-1-(((2S)-2-(5-(4'-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt. The present disclosure also generally relates to intermediates useful in this process.

Process for synthesizing compounds useful for treating hepatitis C

The invention relates to bisaryl derivatives of the formula I,wherein (R,R) is selected from (H,H), O, (H,CH), (H,OH) and (H,CN); Ar is substituted phenyland A is a group of formula II, III, IV or V: An example is (3S,6S)-1-N-(7-phenylheptyl)-3-(4-(3,4,5-trimethoxyphenyl)benzyl)-4-N-methyl-6-methyl-2,5-dioxo-1,4-piperazine: The compounds of the invention have FSH receptor modulatory activity and can be used for the control of fertility, for contraception or for treatment of hormone-dependent disorders.

Bisaryl derivatives having FSH modulatory activity

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Hillsborough, NJ, United States of America

Peng Geng