University of Virginia Patent Foundation

Peng Cui

Timothy L MacDonald

Jerry L Nadler

Phthalazine analogs of a Lisofylline (LSF) and synthetic methods for preparation of such analogs are provided. Compounds of the invention have structural formula III: wherein 1) Ris hydrogen and Ris selected from Calkyl, Calkenyl, or Calkynyl; or a pharmaceutically acceptable salt thereof; or 2) Ris hydrogen and Ris selected from Calkyl, Calkyl, Calkenyl, or Calkynyl; or a pharmaceutically acceptable salt thereof; or 3) Rand Rare the same or different and are selected from Calkyl, Calkyl, Calkenyl, or Calkynyl; or a pharmaceutically acceptable salt thereof. The analogs of LSF provided have the ability to protect cell viability, particularly the ability to protect pancreatic &#x3b2;-cells, to induce insulin secretion.

Substituted phthalazines for inducing insulin secretion and protecting beta-cells

The present invention provides analogs of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF.

Lisofylline analogs and methods for use

Analogs of a Lisofylline (LSF), and synthetic methods for the preparation of such analogs are provided. The analogs of LSF provided have the ability to protect cell viability, particularly the ability to protect pancreatic &#x3b2;-cells.

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Charlottesville, VA, United States of America

Peng Cui