Radi Medical Technologies Ab

Nanospace Ab

Silex Microsystems Ab

Ascilion Ab

Silex Microsystems Ag

Pelle Rangsten

Edvard Kälvesten

Lars Tenerz

Leif Smith

Jonas Tirén

Johan Bejhed

Klas Anders Hjort

Markus Renlund

Carolina Ribbing

Marianne Mechbach

Thorbjörn Ebefors

Niklas Svedin

Lars Stenmark

Edvard Kaelvesten

Hakan Johansson

Mikael Hillmering

Tor-Arne Grönland

Mikael Franzén

Kerstin Jonsson

Tommy Schönberg

Håkan Johansson

Tommy Schoenberg

Thorbjoern Ebefors

Mikael FRANZÉN

Tommy Huhtaoja

A suction applying device () for applying suction to a sampling unit () for sampling bodily fluid, wherein the suction applying device comprises a syringe body () with a hollow interior () and a piston () movable inside the hollow interior of the syringe body. The syringe body has a rear end () through which a piston rod () connected to the piston extends outside of the syringe body and by means of which the piston can be moved, and a front end () opposite the rear end. The suction applying device further comprises a connection arrangement () configured for connection of a sampling unit, wherein the connection arrangement is located at the front end of the syringe body. The suction applying device also comprises a first conduit () having a rear opening () connecting the first conduit to a rear portion () of the hollow interior, in which rear portion a sub-pressure is created when the piston is moved forward inside the hollow interior, and a front opening () by means of which the first conduit is connectable to a sampling unit. The suction applying device also comprises a second conduit () that connects a front portion () of the hollow interior with the exterior of the syringe body, and which front portion is located between the piston and the front end of the syringe body. Also disclosed is an apparatus for sampling bodily fluid, comprising a suction applying device and a sampling unit, as well as a method for detecting a component in a bodily fluid.

Suction applying device, an apparatus for sampling a bodily fluid and a method for detecting a component in a bodily fluid

A microneedle and a chip are disclosed for extraction of fluids. The microneedle () provided on a substrate (), comprises an elongated body () extending from a distal end () with a bevel () to a proximal end () on the substrate along a longitudinal axis; the elongated body comprises a capillary bore () extending in a longitudinal direction thereof and defines a fluid path (); the proximal end is integrally connected with the substrate and the capillary bore is in fluid communication with a fluid channel () of the substrate. The cross-sectional area of the capillary bore in the distal end is larger than the cross-sectional area of the capillary bore in the proximal end.

Microneedle and a chip

A micromechanical pressure relief valve arrangement comprises a stack of wafers. An active pressure relief valve is realized within the stack of wafers. A passive pressure relief valve is also realized within the stack of wafers, arranged in parallel to the active pressure relief valve. A check valve, also realized within the stack of wafers, is arranged in series with both the active pressure relief valve and the passive pressure relief valve.

Pressure relief valve

A wafer assembly () includes a substrate (), in turn including a wafer () or a stack of wafers. The wafer assembly () further includes an electrical connection () arranged through at least a part of the substrate (). The electrical connection () is made by low-resistance silicon. The electrical connection () is positioned in a hole () penetrating at least a part of the substrate (). A surface () of the substrate () confining the hole () is electrically insulating. The electrical connection () has at least one protrusion (), which protrudes transversally to a main extension () of the hole () and the protrusion () protrudes outside a minimum hole diameter (), as projected in the main extension () of the hole (). Preferably, the protrusion () is supported by a support surface () of the substrate (). A manufacturing method is also disclosed.

Substrate-penetrating electrical connections

An isolation valve system includes a main body (), an actuator body () and a sealing membrane () arranged at a high pressure portion () of the isolation valve system. The sealing membrane mechanically attaches the actuator body to the main body. The sealing membrane further seals the high pressure portion from a low pressure portion (). A burst plug () is arranged against the main body and supports the actuator body. An activation arrangement () is arranged for allowing an at least partial displacement of the burst plug, typically causing a phase transition. The sealing membrane is dimensioned to break when the actuator body is moved due to the displacement of the burst plug. The isolation valve system includes preferably a stack () of substrates (-) being bonded together. The substrates have micromechanical structures, which form at least the actuator body and the sealing membrane.

High pressure isolation valve system

A method of making an electrical connection between a first (top) and a second (bottom) surface of a conducting or semi-conducting substrate includes creating a trench in the first surface, and establishing an insulating enclosure entirely separating a portion of the substrate, defined by the trench. Also described is a product usable as a starting substrate for the manufacture of micro-electronic and/or micro-mechanic devices, including a flat substrate of a semi-conducting or conducting material, and having a first and a second surface and at least one electrically conducting member extending through the substrate. The electrically conducting member is insulated from surrounding material of the flat substrate by a finite layer of an insulating material, and includes the same material as the substrate, i.e. it is made from the wafer material.

Electrical connections in substrates

In manufacturing a pressure sensor a recess that will form part of the sensor cavity is formed in a lower silicon substrate. An SOI-wafer having a monocrystalline silicon layer on top of a substrate is bonded to the lower silicon substrate closing the recess and forming the cavity. The supporting substrate of the SOI-wafer is then etched away, the portion of the monocrystalline layer located above the recess forming the sensor diaphragm. The oxide layer of the SOI-wafer here acts as an 'ideal' etch stop in the case where the substrate wafer is removed by dry (plasma) or wet etching using e.g. KOH. This is due to high etch selectivity between silicon and oxide for some etch processes and it results in a diaphragm having a very accurately defined and uniform thickness. The cavity is evacuated by forming a opening to the cavity and then sealing the cavity by closing the opening using LPCVD. Sensor paths for sensing the deflection of the diaphragm are applied on the outer or inner surface of the diaphragm. The monocrystalline diphragm gives the sensor a good long-term stability. Also the sensor path can be made of monocrystalline material, this giving the sensor even better good long-term characteristics. An increased sensitivity can be obtained by making active portions of the sensor paths freely extending, unsupported by other material of the pressure sensor, by suitable etching procedures.

Pressure sensor

A miniaturized X-ray source is disclosed. It comprises an anode structure () and a cathode structure (), each having an essentially pointed portion (), wherein at least the pointed portions being directed towards each other and enclosed in a vacuum cavity (). The anode structure has an essentially dome shaped structure having a first essentially flat part () surrounded by a second essentially flat part (), connected by a wall section (), such that said first and second parts are located at different levels. The pointed portion is provided on said first flat portion and having an extension such that the apex of said pointed portion does not extend beyond the level of said second essentially flat part. A method of making an X-ray source is also disclosed.

X-ray tube electrodes

An X-ray source includes a first support member and a second support member joined together so as to form a cavity between them and such that they are electrically insulated from each other. A cathode and an anode are located inside the cavity and opposite each other. The cathode is suitably made of diamond or diamond like material, and includes at least one pointed element.

Miniature x-ray source

A method and a system for x-ray treatment of, for example, cancer or restenosis prevention inside a living body is disclosed. A miniature x-ray tube (,) is provided with at least one pair of electrodes (,), the electrodes alternatingly serving as anode and cathode, respectively. A power supply (,) is connected to the electrodes, and a switching unit of the power supply alternates the electrical potential across the electrodes. With the x-ray tube according to the invention the temperature increase at the site of treatment is limited, thereby providing an effective treatment without unduly prolonged treatment duration.

Miniature x-ray tube with voltage selective electrodes

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Storvreta, Sweden

Pelle Rangsten