Merck Sharp + Dohme Corp.

Microsoft Technology Licensing, LLC

Pek Yee Lum

John R Thompson

Joel Peter Berger

Hongyue Dai

Eric Stanley Muise

Richard F Raubertas

Yejun Tan

Kenny Kin Chung Wong

Serguei B Stepaniants

Eric E Schadt

Roy Kuraisa

Rebecca Kaplan

Tian-Quan Cai

In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.

Methods for characterizing agonists and partial agonists of target molecules

Systems and methods for determining a functional relationship between pairs of cellular constituents are provided. A plurality of datasets is received. Each dataset represents an experimental condition and comprises measurement data for a plurality of cellular constituents from each of a plurality of organisms. Each respective dataset is represented by correlation coefficients. Each correlation coefficient for a respective dataset in the plurality of datasets represents a correlation between abundance measurement data for a pair of cellular constituents across the dataset. The plurality of correlation coefficients that represents a first dataset in the plurality of datasets is clustered, thereby determining their order. This order is applied to each remaining dataset thereby forming a plurality of correlation matrices. When a conserved area in the plurality of matrices is identified, the functional relationship between the first cellular constituent and the second constituent is determined to be present.

Computer systems and methods for identifying conserved cellular constituent clusters across datasets

The present invention provides methods for screening for one or more chemical agents that modulate the enzymatic activity of an L-2-hydroxy acid oxidase. The methods comprise the steps of (a) contacting an L-2-hydroxy acid oxidase, in a solution in vitro, with one or more chemical agents in the presence of a substrate that is capable of being oxidized by the L-2-hydroxy acid oxidase; (b) measuring the enzymatic activity of the L-2-hydroxy acid oxidase in the presence of the chemical agent to identify one or more candidate chemical agents that modulate L-2-hydroxy acid oxidase activity in vitro; and (c) administering the one or more identified candidate chemical agents to a test animal and measuring one or more physiological parameters.

Methods for determining whether a chemical agent modulates enzymatic activity of an L-2-hydroxy acid oxidase

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Pek Yee Lum