Other

Shandong Academy of Pharmaceutical Sciences

Shandong Freda Pharmaceutical Group Co., Ltd.

Meyer Bio-Medicine Co., Ltd.

Shandong Meimao Pharmaceutical Co., Ltd.

Shandong Guantianxia Biotechnology Co., Ltd.

Ling, Peixue

Peixue Ling

Huarong Shao

Yanli He

Jianying Chen

Jie Liu

Yan Xi Jin

Lei Chen

Xueping Guo

Yanling Cheng

Jianqiang Zhang

Qingkai Zeng

Daizhou Zhang

Xiaoyuan Zhang

Tianmin Zhang

Zhiyun Zhang

Fei Liu

Qixin Chen

Guanying Han

Chenglei Shao

Ling Zhang

Lixia Shang

Zhiping Fan

Tao Ji

Yan Jin

A preparation method of sodium hyaluronate with a full molecular weight distribution (MWD) is provided, including: step 1): spraying hydrogen peroxide on a sodium hyaluronate solid raw material, and conducting an ultraviolet (UV) irradiation treatment; step 2): dissolving a sodium hyaluronate degradation material in water, and adjusting a pH to higher than 7.0; step 3): subjecting a sodium hyaluronate alkaline solution to an ultrasonic treatment; step 4): preparing the sodium hyaluronate solid raw material into a sodium hyaluronate solution with a concentration of 0.1% to 1% (w/v), and thoroughly mixing the sodium hyaluronate solution in an addition proportion of 20% to 60% (v/v) with the sodium hyaluronate alkaline solution obtained after the ultrasonic treatment; and step 5): subjecting a resulting mixed solution to an adsorption treatment with diatomaceous earth and activated carbon, filtering for concentration, and drying a resulting concentrate to obtain the sodium hyaluronate with a full MWD.

Sodium hyaluronate with full molecular weight distribution (MWD), and preparation method and use thereof

A joint cavity injection preparation is provided. The active ingredient of the joint cavity injection preparation is deacetylated xanthan gum (XG). The deacetylated XG has a molecular weight of 500,000 to 20,000,000. The joint cavity injection preparation is prepared from deacetylated xanthan gum (XG), which has higher biocompatibility and safe wide-dosage range than existing joint cavity injection preparations prepared from XG.

Joint cavity injection preparation and use thereof

The present invention relates to a method for preparation of heparin silver, to use of heparin silver in manufacture of medicine for treating burns and/or scalds, to a method of using heparin silver to treat burns and/or scalds, and to a topical preparation containing heparin silver for treating burns and/or scalds. The heparin silver product prepared according to the method of the present invention has a high purity and less impurity. The animal test proved that the medicine made by using heparin silver exhibited effects of accelerating wound healing and reducing scar formation.

Preparation and application of heparin silver

The present invention discloses a bismuth hyaluronate, characterized in that the bismuth content is from 0.5% to 40%, and the glucuronate content is from 20% to 45%, based on dry weight. Also provided is a method for the preparation of said bismuth hyaluronate comprising reaction of a soluble hyaluronate salt with a bismuth salt in a basic aqueous solution, followed by steps of precipitation, filtration, desalting, dehydrating and drying to obtain the product. Further disclosed is the use of the bismuth hyaluronate in the manufacture of a medicament or health foods for preventing and treating gastrointestinal disorders, in particular ulcerous disorders of the GI tract. It has been proven in animal experiments to show a better therapeutic effect than products of the same type.

Bismuth hyaluronate, the preparation method and the use thereof

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Jinan, China

Peixue Ling