Chinese Academy of Sciences

Zhejiang University

Baker Hughes Oilfield Operations LLC

Peipei Wang

Jia Tao Li

Yubo Zhou

Anhui Gao

Mingbo Su

Tao Liu

Yongzhou Hu

Xiaowu Dong

Xiaobei Hu

Pinrao Song

Lexian Tong

Daniel Abawi

Jianjun Jiang

Guijun Zhang

Xibin Yang

Daxi Xiong

Jia Li

A structured illumination microscopic imaging system includes a structured illumination source. A beam shaping lens, an excitation optical filter and a dichroic mirror are provided on the emission light path of the structured illumination source in sequence. An objective lens and a sample are provided on the first optical path of the dichroic mirror in sequence. An emission optical filter, a tube lens, and a detector are provided on the second optical path of the dichroic mirror in sequence. The super-resolution microscopic images with a higher signal-to-noise ratio and higher contrast can be obtained under the premise of lowering the installation and processing precision requirements of the structured illumination microscopic imaging system. Compared to a structured light microscopic imaging system based on digital micromirror arrays or gratings, the system cost is reduced and the system stability is higher.

Structured illumination microscopic imaging system

The present invention provides a 2-polysubstituted aromatic ring-pyrimidine derivative and an optical isomer thereof, or a pharmaceutically acceptable salt or solvate thereof, the compound, and an optical isomer thereof or a pharmaceutically thereof acceptable salts or solvates can be used in the preparation of anti-tumor drugs. The invention designs and synthesizes a series of novel small molecule Chk1 inhibitors by using N-substituted pyridin-2-aminopyrimidine obtained by structure-based virtual screening as a lead compound, and carries out Chk1 kinase inhibitory activity test. The experiment confirmed that said compounds possess potent anticancer activity, Chk1 kinase inhibitory activity, and are promising Chk1 inhibitors, and can be used as new cancer therapeutic drugs, which can be applied to treat solid tumors or hematologic tumors related to proliferative disease of human or animal. The 2-polysubstituted aromatic ring-pyrimidine derivatives provided by the present invention has the structure of the formula I: 

2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof

A method includes receiving data characterizing an output of a sensor coupled to an industrial equipment. The output can include a sum of a first secondary coil and a voltage of a second secondary coil. The first secondary coil can be included in a first circuit and the second secondary coil can be included in second circuit configured within the sensor. The method can also include determining an integrity state of a circuit configured within the sensor. The integrity state can be determined based on the received data. The integrity state can identify a state of operation of the circuit configured within the sensor. The method can further include providing the integrity state. Related systems, techniques, and non-transitory computer readable mediums are also described.

Sensor circuit diagnosis

A 2-substituted aromatic ring-pyrimidine derivative as shown in a general formula I, and an optical isomer or a pharmaceutically acceptable salt or a solvate thereof are provided. The present invention designs and synthesizes a series of novel small molecular Chk1 inhibitors by using N-substituted pyridin-2-aminopyrimidine obtained through structure-based virtual screening as a lead compound, and carries out Chk1 kinase inhibitory activity test. The experiment confirmed that said compounds possess strong anti-cancer effect, Chk1 kinase inhibitory activity and are promising Chk1 inhibitors. The compounds can be used as new cancer therapeutic drugs, which can be applied to treat solid tumors or hematologic tumors related to proliferative disease of human or animal.

2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof

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Shanghai, China

Peipei Wang