University of California

Pei Yuin Keng

Chang-Jin Kim

R Michael Van Dam

Gaurav Shah

Supin Chen

Huijiang Ding

Kyoung-Joo Jenny Park

Rehana Ismail

Ariella Machness

Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containingF.

Digital microfluidic platform for radiochemistry

The present disclosure relates to the novel multistep procedure for preparation of polymer monoliths for use in solvent exchange, such as methods to exchange and activate fluoride ions on a flow through microfluidic chip for subsequent chemical synthesis. Methods according to the present disclosure include the application of such microfluidic platforms for rapid F18 radiosynthesis on a flow through microfluidic chip with high efficiency, followed by a subsequent nucleophilic fluorination reaction. Various other methods of exchanging and activating fluoride ions on a flow through microfluidic chip are also disclosed. Methods incorporating features of the present invention can be applicable to any flow through microfluidic device in any field, such as radiosyntheses, chemical syntheses, concentration of ions for environmental analyzes and sample preparation such as concentrating minute amounts of analyte to improve the downstream detection.

Polymer monoliths for solvent exchange in continuous flow microfluidic device

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Los Angeles, CA, United States of America

Pei Yuin Keng