Other

Jinan University

Panorama Research Inc.

Well Resources Limited

Guangzhou Magpie Pharmaceuticals Co., Ltd.

Guangzhou Magpie Pharmaceutical Co., Ltd.

Pei Yu

Yuqiang Wang

Yewei Sun

Zaijun Zhang

Gaoxiao Zhang

Peng Yi

Luchen Shan

James W Larrick

Zheng Liu

Jie Jiang

Haiyun Chen

Liang Tao

Wei Liu

Chunming Xu

Peng Fei Yi

Quan Shi

Keng Chung

Suoqi Zhao

Zhiming Xu

Ming Liang

Mei Jing

Xiaojian Jiang

Lipeng Xu

Jing Du

Keng H Chung

Mengtao Cui

Xuebing Li

Warren Chung

Zhaoqi Yang

Moussa B H Youdim

Linda Wang

Zaizun Zhang

Ming Lang

James Larrick

Moussa BH Youdim

The present invention provides uses of an andrographolide derivative in preparation of a medicament for preventing and treating inflammatory bowel disease. The andrographolide derivative AL-1 has the mechanisms, for the treatment of ulcerative colitis, of scavenging of free radicals, inhibition of NF-κB signaling pathway activation and COX-2 expression, activation of PPAR-γ expression, and thus can prevent the transcription and expression of inflammatory-related genes to improve the conditions of inflammation. AL-1 can be used as a medicine for the treatment of inflammatory bowel disease and can be formulated to various dosage forms with a pharmaceutically acceptable carrier.

Use of andrographolide derivatives in preparation of medicaments for preventing and treating inflammatory bowel diseases

A method of treating or remediating contaminated material, such as water or soil, comprises contacting such material with asphaltenes. The asphaltenes are preferably produced as a by-product of petroleum refining and, in particular, a by-product of vacuum residua. An adsorbent material comprising such asphaltenes is also provided.

Method for treating pollutants

A use of of ligustrazine nitrone derivatives and a pharmaceutical composition thereof in the preparation of medicine for preventing and treating diabetic complication diseases. The ligustrazine nitrone derivatives can be prepared into various dose forms together with drug carriers.

Use of ligustrazine nitrone derivatives in prevention and treatment of diabetic complication diseases

The present invention relates to amantadine nitrate compounds having neural protective effect, and preparation method and medical use thereof. The compounds have the structure of the general formula (II).  The compounds have multifunctional mechanisms, including inhibiting NMDA receptors, releasing NO, inhibiting calcium influxes, and having protective effects on cells particularly neurocytes. The compounds can be used in the preparation of medicaments having a cellular protective effect, for prevention or treatment of the diseases related to such as NMDA receptors and elevation of calcium anions in cells, including the diseases related to neurodegeneration such as Alzheimer's disease, Parkinson's disease, cerebral paralysis and glaucoma, and the diseases related to cardio-cerebral-vascular system such as Parkinson's syndrome combined with cerebral arteriosclerosis, as well as respiratory tract infections caused by influenza virus.

Amantadine nitrate compounds for use as medicaments for the treatment of diseases

The present invention relates to a pyrazine derivative, and preparation method and medical use thereof. The pyrazine derivative can remove free radicals and suppress calcium overload and has cytoprotective effects, and can be used for the prevention and treatment of cardiovascular and cerebrovascular diseases, neurodegenerative diseases and other related diseases.

Pyrazine derivative, and preparation method and medical use thereof

The present invention relates to trifluoroacetyl hydrazide compounds and medical uses thereof. The compounds have a structure of the following formula:  The compounds showed multifunctional mechanisms, including inhibition of glutamate excitotoxicity, activation of MEF2 transcriptional activity, clearance of free radicals, and promotion of nerve differentiation, and has a better protective effect on cells especially nerve cells. The compound can be used to prepare prophylactic or therapeutic medicaments with cytoprotective effects, for the prevention or treatment of diseases related to glutamate receptor activation, MEF2 disorders or excessive free radicals generation. The diseases include, for example, neurodegenerative diseases such as Alzheimer's disease, Parkinson and stroke, and the free radicals related diseases such as heart disease, myocardial ischemia, diabetes and other cardiovascular and cerebrovascular diseases.

Trifluoroacetyl hydrazide compounds and medical uses thereof

The present invention relates to trifluoroacetyl hydrazide compounds and methods of preparation and uses thereof. The compounds have a structure of the following formula:  The compounds showed multifunctional mechanisms, including inhibition of glutamate excitotoxicity, activation of MEF2 transcriptional activity, clearance of free radicals, and promotion of nerve differentiation, and has a better protective effect on cells especially nerve cells. The compound can be used to prepare prophylactic or therapeutic medicaments with cytoprotective effects, for the prevention or treatment of diseases related to glutamate receptor activation, MEF2 disorders or excessive free radicals generation. The diseases include, for example, neurodegenerative diseases such as Alzheimer's disease, Parkinson and stroke, and the free radicals related diseases such as heart disease, myocardial ischemia, diabetes and other cardiovascular and cerebrovascular diseases.

Trifluoroacetyl hydrazide compounds and methods of preparation and uses thereof

The present invention relates to amantadine nitrate compounds having neural protective effect, and preparation method and medical use thereof. The compounds have the structure of the general formula (I). The compounds have multifunctional mechanisms, including inhibiting NMDA receptors, releasing NO, inhibiting calcium influxes, and having protective effects on cells particularly neurocytes. The compounds can be used in the preparation of medicaments having a cellular protective effect, for prevention or treatment of the diseases related to such as NMDA receptors and elevation of calcium anions in cells, including the diseases related to neurodegeneration such as Alzheimer's disease, Parkinson's disease, cerebral paralysis and glaucoma, and the diseases related to cardio-cerebral-vascular system such as Parkinson's syndrome combined with cerebral arteriosclerosis, as well as respiratory tract infections caused by influenza virus.

Amantadine nitrate compounds with neural protective effect, and preparation and medical use thereof

The invention generally relates to compounds of formula (I) with neural protective effect, and preparation and uses thereof.  The compounds have multiple mechanisms or functions, for example, inhibition of monoamine oxidase and cholinesterase, scavenging of free radicals, and protection of cells such as nerve cells. The compounds can be used for manufacture of medicaments of cell protection, for prevention and/or treatment of monoamine oxidase, cholinesterase and free radicals related diseases, for example, neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and stroke, and free-radical related diseases such as heart disease, myocardial ischemia, diabetes and other cardiovascular and cerebrovascular diseases.

Compounds with neural protective effect, and preparation and use thereof

The invention discloses a high strength nodular cast iron pole and a preparation technology thereof. The preparation technology is characterized by comprising the following steps: (1) preparation before pole casting, to be specific, preparation of raw materials, smelting of iron, adding of alloying elements and nodulizing; (2) a pole casting procedure, to be specific, casting and inoculation treatment; and (3) heat treatment. The invention also provides the high strength nodular cast iron pole prepared by adopting the preparation technology, comprising multiple tower poles which are sequentially connected in an inserted manner, wherein each tower pole is a cone-frustum hollow column which has the conicity of 1000:11-26; the top end of the high strength nodular cast iron pole is equipped with a tower cap. The high strength nodular cast iron pole has the advantages of high bearing capacity, thin wall thickness, light weight, low manufacturing cost and the like.

High strength nodular cast iron pole and preparation technology thereof

The present invention provides pyrazine derivatives of formula I and pharmaceutically acceptable salts thereof, wherein the designation of R, R, Rand Ris provided herein. The invention also provides syntheses for preparation of such compounds. The invention further provides methods of use of these compounds and pharmaceutical compositions containing them for treatment and/or prevention of diseases and for manufacture of medicaments. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and/or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and/or prevention of nervous system diseases caused by excessive amount of radicals and/or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.

Lighting device having at least one heat sink

The present invention provides novel nitrones, their preparation and use. The novel compounds have the following formula: I The compounds of the present invention have strong antioxidative activity, and are thrombolytic. These compounds can be used to treat and/or prevent diseases caused by overproduction of free radicals and/or formation of thrombus. 

Nitrone compounds, process of preparation thereof, and use thereof in medicament manufacture

The present invention relates to an andrographolide derivative of the formula (I), wherein R, Rand Rare same or different substituents selected from hydrogen, substituted or unsubstituted organic acid radicals, inorganic acid radicals, alkyl, aryl or heteroaryl, and at least one of R, Rand Ris R-lipoic acid, S-lipoic acid or a mixture thereof, or corresponding dihydrolipoic acids thereof, or N-acetylcysteine radical. The derivative has good antitumor effect, can induce apoptosis of tumor cells, can directly kill Gram-positive bacteria () and drug resistance bacteria (MRSA5676 and MRSA5677), can inhibit the QS-system of Gram-negative bacteria (), can inhibit and destroy the formation of biofilm of; and exhibits significant hypoglycemic effect, so that it can be used in manufacture of medicaments for treatment of cancers, inflammation, diabetes, and bacterial and viral infections. 

Andrographolide derivatives and use thereof in manufacture of medicaments

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Guangzhou, China

Pei Yu