Academia Sinica

Pei-wen Hsiao

Shih-Chuan Hsieh

Chin-Hsien Tsai

Yi-Chun Yeh

Chia-Ying Wu

Shu-Mei Liang

Sheng-Yang Wang

Ming-Chu Cheng

Ming-Shyue Lee

Yu-Chih Yang

Sheue-Fen Tzeng

Feng-Min Lin

The present invention relates to biomarkers, methods and assay kits for predicting prognosis and/or monitoring progression of prostate cancer. The biomarkers include a glycosyltransferases [core 1 beta-3-galactosyltransferase (C1GALT1) and/or ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3GAL1)] gene product, its saccharide substrate/product, and/or a galectin-4 gene product.

Biomarkers for predicting prostate cancer progression

A composition including a standardizedextract and a method of treating an androgen-stimulated disorder with such a composition. Also provided are a method for qualifying a standardized preparation of aextract for treating an androgen-stimulated disorder and a method for treating said disorder with a thus qualified preparation.

Development of a standardized and effect-optimized herbal extract ofand its use for treating disease

A method for preparing a standardizedextract and an extract prepared by the method. Also provided is a method for qualifying the standardized extract by characterizing its most abundant compounds and its biological activity in vitro. Additionally, a method is provided for treating an androgen-stimulated disorder with the qualifiedextract.

A vaccine composition is disclosed. The vaccine composition comprises: (a) a therapeutically effective amount of an influenza virus-like particle (VLP) comprising: (i) influenza M1, influenza M2, influenza hemagglutinin (HA), and influenza neuraminidase (NA) proteins; (b) Foot-and-mouth disease virus (FMDV) capsid protein VP3, recombinant FMDV VP3 (rVP3), VP3 peptide, or SUMO VP3; and (c) alum. Also disclosed is use of a vaccine composition according to the invention in the manufacture of a medicament for inducing an immunogenic response in a subject in need thereof.

Bird flu vaccine combination comprising virus-like particles and novel adjuvants

Virus-like particles (VLPs) of mammalian-hosted viruses, such as SARS-CoV and influenza viruses, have been recombinantly produced from Vero cells. The VLPs closely emulate the exterior of authentic virus particles and are highly immunogenic. They can elicit not only humoral but also cellular immune responses in a mammal. Compositions and methods related to the VLPs are also described.

High-yield transgenic mammalian expression system for generating virus-like particles

Disclosed herein is a method for treating an androgen-stimulated disease in a subject in need thereof by administering to the subject a composition containing an effective amount of an inhibitor of I&#x3ba;B kinase subunit &#x3b1; activity. The composition can also be administered to a subject at high risk for prostate cancer as a method for reducing the subject's risk thereof. A further method relates to identifying a modulator of transcriptional activity regulated by I&#x3ba;B kinase subunit &#x3b1;. Still another method relates to determining the I&#x3ba;B kinase subunit &#x3b1;-regulated transcriptional activity regulated by in a non-human mammalian test subject.

Transcription modulator compositions

The present invention discloses certain diterpenes that can be used to inhibit androgen receptor activity, induce apoptosis and block cell cycle progression of androgen receptor-dependent cells. Androgen receptor has been associated with various diseases such as prostate cancer, androgeneic alopecia, breast cancer, acne etc. Accordingly, the present invention further discloses methods of treating androgen receptor-associated diseases by administering the disclosed diterpenes.

Growing community of inventors

Taipei, Taiwan

Pei-wen Hsiao