Sangamo Biosciences, Inc.

Sangamo Therapeutics, Inc.

Pei-Qi Liu

Edward J Rebar

Stephen P Eisenberg

Eric E Jarvis

Andrew Jamieson

Qiang Liu

Alan P Wolffe

Jeffrey C Miller

Lei Zhang

Andreas Reik

Elizabeth J Wolffe

Methods and compositions for treatment of a beta thalessemia are provided.

Methods and compositions for treatment of a beta thalessemia

Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.

Methods and compositions for inactivating glutamine synthetase gene expression

Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.

Regulation of angiogenesis with zinc finger proteins

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Richmond, CA, United States of America

Pei-Qi Liu