Abgenomics Cooperatief U.a.

Abgenomics Corporation

Pei-Ling Hsu

Rong-Hwa Lin

Chung-Hsiun Wu

Compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The compounds and methods of the invention can be used to control unwanted T cell- or NK cell-mediated immune responses in conditions such as autoimmune diseases, transplant rejection, and allergic diseases.

Screening for modulators of PSGL-1 with respect to T cell or NK cell death

Methods of modulating T cell-mediated immune responses with anti-P-selectin glycoprotein ligand 1 antibodies

Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies

The invention is directed to methods of producing a protein by administering a nucleic acid encoding the protein to an animal. Following the administration of the nucleic acid to the animal, the protein is produced in vivo and is isolated by removing a biological sample from the animal. These methods allow for the rapid and efficient production and isolation of a protein encoded by any nucleic acid sequence of interest and can be used to generate antibodies that bind to the protein sequence.

Growing community of inventors

Little Rock, AR, United States of America

Pei-Ling Hsu