Metal Industries Research & Development Centre

Kaohsiung Medical University

Pei-Jung Lien

Yang-Chang Wu

Fang-Rong Chang

Ying-Chi Du

Tzu-Chen Kuo

Chung-Yi Chen

Yi-Hong Tsai

Tusty-Jiuan Hsieh

A-Mei Huang

Sheng-Chung Yang

Chuan-Chia Sun

Yu-Ren Huang

Tz-Choung Chou

Ren-Wei Su

Jih-Heng Li

Chiung-Hui Liu

The present disclosure provides aextract, process for manufacturing the same, and uses thereof for inhibiting differentiation and/or activation of osteoclast, and prevention and/or treatment of osteoporosis.

extract, process for manufacturing the same and uses thereof

Theextract of the present invention is prepared using supercritical fluid technique, wherein the method includes steps of: (a) drying the leaves of; (b) pulverizing the leaves as particles; and (c) extracting the particles with supercritical carbon dioxide to obtain theextract. This supercriticalextract not only can decrease blood sugar level, but also promotes lipid degradation, inhibits the formation of huge lipid droplet and improves the metabolic symptoms. Accordingly, theextract further is able to be prepared as food supplement and pharmaceuticals.

Extract offrom supercritical fluid extraction for treating diabetes and metabolic disease, the preparation method and the use thereof

What is disclosed in the invention is a preparation method of a supercriticalextract, which is made from the material, the dried stem of. The extract is obtained by extractingwhich is pulverized as particles with supercritical carbon dioxide fluid. Theextract or its active ingredient, subamolide A, can be used to inhibit the growth of human urothelial carcinoma cell lines. In addition, theextract (or subamolide A) is able to synergistically inhibit the growth of human urothelial carcinoma cell lines with cisplatin (CDDP) or gemcitabine (Gem). Therefore, theextract (or subamolide A) can be an anticancer drug alone, or forms a pharmaceutical composition with CDDP (or Gem) to treat with cancers in respect of urinary system.

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Pei-Jung Lien