Industrial Technology Research Institute

Arjil Biotech Holding Company Limited

Pei-Hsin Lin

Jir-Mehng Lo

Kuo-Kuei Huang

Meng-Nan Lin

Yeh B Wu

I-Horng Pan

Yi-Cheng Cheng

Jennline Sheu

Pei-Ru Liau

Hui Ju Liang

Chu-Hsun Lu

I-Hong Pan

Shu-Fang Wen

Zong-Keng Kuo

Hao Chiang

Cheng F Huang

I-Huang Lu

Hui-Ju Liang

Ya-Yan Yang

Jia-Horng Liaw

Cheng Huang

Wei-Chung Chiou

Tze-Chung Lee

Tze- Chung Lee

The present invention pertains to anti-coronaviral compounds. The disclosure includes a method for preventing and/or treating a coronavirus infection through the inhibition of a cysteine protease in a virus, particularly SARS-COV-2. Also provided includes the composition/pharmaceutical composition for preventing and/or treating a coronavirus infection comprising any of the compounds, pharmaceutically acceptable salt thereof, or its mixture, and the use of the compounds.

Compounds and methods for prevention and treatment of coronavirus infections

A method of treating or alleviating autoimmune-related diseases is provided. The method includes administering a pharmaceutical composition to a subject in need thereof. Moreover, the pharmaceutical composition includes an extract of-as an effective ingredient and a pharmaceutically acceptable carrier or salt.

Method for treating or alleviating autoimmune-related diseases

A method of treating or alleviating autoimmune-related diseases is provided. The method comprises administering a pharmaceutical composition to a subject in need thereof. Moreover, the pharmaceutical composition comprises an extract of Amomum tsao-ko as an effective ingredient and a pharmaceutically acceptable carrier or salt.

A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof: whereinis a single or double bond, X is NCHor CH, Y is null, O or N, Z is O or N, Ris H, OH, and Ris null, H, C-Calkyl, &#x2014;(C&#x2550;O)-alkyl, &#x2014;(C&#x2550;O)-aryl, &#x2014;(C&#x2550;O)-alkyl-aryl, &#x2014;(C&#x2550;O)-heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of &#x2014;OH, &#x2014;NO, &#x2014;NH, &#x2014;NRR, carbonyl, alkoxyl, alkyl or &#x2014;OCF, wherein Rand Rindependently are H, alkyl, &#x2014;SOCH, &#x2014;(C&#x2550;O)&#x2014;CHor &#x2014;(C&#x2550;O)&#x2014;NH.

Method for treating an autoimmune neurological disease and/or neurodegenerative disease and pharmaceutical formulations for a liquid dosage form and a controlled release dosage form

The present invention pertains to a composition for preparing a medicament for preventing and/or treating a virus infection, especially a hepatitis B virus infection and/or a herpes simplex virus, and uses thereof.

Method and composition for inhibiting virus infection

The invention relates to a use of a compound for manufacturing a medicament for treating an allergic disease, wherein the compound is selected from the group consisting of ovatodiolide, 1'-acetoxychavicol acetate, zerumbone and combination thereof. Also provided is a method and a composition for treating an allergic disease.

Method for treating an allergic disease

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Hsinchu, Taiwan

Pei-Hsin Lin