Centre National De La Recherche Scientifique

Universite Claude Bernard – Lyon1

Université Grenoble Alpes

Centre National De La Recherche Scientifique-cnrs

Centre Leon Berard

Institut National De La Sante Et De La Recherche Medicale (inserm)

Université De Caen Normandie

Peggy Suzanne

Sylvain Rault

Renaud Prudent

Patrick Dallemagne

Eric Denarier

Laurence Lafanechère

Marc Billaud

Audrey Vernet

Jean-charles Lancelot

Serge Perato

Lauralie Peronne

Martine Cordier-bussat

Aurélien Lesnard

Eric Fontaine

The invention concerns a compound of formula (I), Formula (I), wherein R, Rand Rare independently selected form the group consisting of: —a hydrogen atom, —a halogen atom, —an alkyl group, linear, cyclic or branched, saturated or unsaturated, possibly substituted, comprising from 1 to 10 carbon atoms, —an acyl group comprising from 1 to 10 carbon atoms, —a carboxyl group, —an amido group comprising from 1 to 10 carbon atoms, and —an imino group, possibly substituted by an alkyl group, linear, cyclic or branched, saturated or unsaturated, and wherein R, R, Rand Rare independently selected form the group consisting of: —a hydrogen atom, —a halogen atom, —a hydroxyl group, —an alkyl group, linear, cyclic or branched, saturated or unsaturated, possibly substituted, comprising from 1 to 10 carbon atoms, —an alkoxy group comprising from 1 to 10 carbon atoms, —an acyl group comprising from 1 to 10 carbon atoms, —a carbonate group from 1 to 10 carbon atoms, —a carboxyl group, and —a cyano group.

Carbazole derivatives sensitizing cells to anti-cancer agents

The invention relates to compounds of formula (I) as follows: (I) wherein Xand X, identical or different, are NRor a sulfur atom, Y is a group (C-C)alkanediyl, Arand Ar, identical or different, are an aryl group optionally substituted by one or several groups selected from a halogen atom, a (C-C) alkyl, —OR, —NRRand —COOR' with Rand R, independently of each other, are a hydrogen atom, a (C--C) alkyl group or a —CORgroup, Rand R′ independently of each other, are a hydrogen atom or a (C-C) alkyl group, and Ris a hydrogen atom or a (C-C)alkyl group, or a pharmaceutically acceptable salt and/or solvate thereof, in particular for use in cancer treatment.

Mitochondrial activity inhibitors targeting tumoral metabolism

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Cairon, France

Peggy Suzanne