Collagen Matrix, Inc.

Peggy Hansen

Shu-Tung Li

Debbie Yuen

This invention relates to a sheet membrane for repairing a damaged tissue. The membrane includes an isotropic layer of cross-linked biopolymeric fibers in which the fibers are 10 to 1,000 cm in length. This invention also relates to a method of making an isotropic layer of cross-linked biopolymeric fibers. The method includes: (1) coacervating biopolymeric fibers (e.g., collagen-based fibers) having lengths of less than 1 cm dispersed in an aqueous solution to obtain coacervated biopolymeric fibers having lengths of 10 to 1,000 cm; (2) flattening the coacervated biopolymeric fibers into a layer; (3) drying the layer; and (4) cross-linking the biopolymeric.

Biopolymeric membranes

A cell occlusion sheet membrane adapted for repairing a damaged meningeal tissue. The sheet membrane contains a layer of cross-linked, oriented biopolymeric fibers that has a thickness of 0.1 mm to 3.0 mm, a density of 0.1 g/cmto 1.2 g/cm, a hydrothermal shrinkage temperature of 45&#xb0; C. to 80&#xb0; C., a suture pullout strength of 0.1 kg to 5 kg, a tensile strength of 10 kg/cmto 150 kg/cm, and permeability to molecules having molecular weights of 200 to 300,000 daltons. Also disclosed is a method for making the membrane.

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Mahwah, NJ, United States of America

Peggy Hansen