Synthetic Genomics, Inc.

Hummingbird Diagnostics Gmbh

Comprehensive Biomarker Center Gmbh

Febit Holding Gmbh

Codex Dna, Inc.

Peer Friedrich Staehler

Markus Beier

Andreas Keller

Eckart Meese

Anne Borries

Raphael Carapito

Cord F Staehler

Joachim Jaeger

Jack Thacher Leonard

Manfred Mueller

Mark Matzas

The invention relates to methods and devices for preparing synthetic nucleic acids.

Synthesis of sequence-verified nucleic acids

The present invention provides novel methods for diagnosing diseases based on the determination of specific miRNAs that have altered expression levels in disease states compared to healthy controls.

MiRNA fingerprint in the diagnosis of multiple sclerosis

The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.

miRNA fingerprint in the diagnosis of diseases

The invention relates to methods for the preparation of synthetic nucleic acids, such as double-stranded nucleic acids. The methods involve the preparation of a multiplicity of different nucleic acid fragments by solid-phase synthesis, and the joining together of at least two of the multiplicity of the nucleic acid fragments by binding to one another or by covalent linkage. In the methods at least some of the nucleic acid fragments have a high AT content and are used in an increased amount relative to other fragments for the joining step.

Programmable oligonucleotide synthesis

miRNA fingerprint in the diagnosis of multiple sclerosis

The invention relates to an extraction method for isolating target molecules from a sample using a microfluidic carrier.

Microfluidic extraction method

Growing community of inventors

Mannheim, Germany

Peer Friedrich Staehler