Algeta Asa

Bayer As

Peer Børretzen

Jan Roger Karlson

Bjørn Haugseter

The present invention relates to a method for the generation ofRa of pharmaceutically tolerable purity comprising: i) preparing a generator mixture comprisingAc,Th andRa in a first aqueous solution comprising a first mineral acid; ii) loading said generator mixture onto a DGA separation medium (e.g. resin); iii) eluting saidRa from said DGA separation medium using a second mineral acid in a second aqueous solution to give an elutedRa solution; and iv) stripping the DGA separation medium of saidAc andTh by flowing a third mineral acid in a third aqueous solution through the DGA separation medium in a reversed direction; The invention further relates to high purity radium-223 formed or formable by such a method as well as pharmaceutical compositions comprising such radium-223 of pharmaceutical purity.

Isotope production method

The present invention provides a method for the generation ofRa of pharmaceutically tolerable purity comprising i) preparing a generator mixture comprisingAc,Th andRa; ii) loading said generator mixture onto a strong base anion exchange resin; iii) eluting saidRa from said strong base anion exchange resin using a first mineral acid in an alcoholic aqueous solution to give a first elutedRa solution; iv) loading theRa of the first elutedRa solution onto a strong acid cation exchange resin; and v) eluting theRa from said strong acid cation exchange resin using a second mineral acid in aqueous solution to provide a second eluted solution. The invention additionally provides products of corresponding purity and/or products obtained or obtainable by such a method.

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Nærsnes, Norway

Peer Børretzen