Bayer Aktiengesellschaft

Pedro Paz

Beatrix Stelte-Ludwig

Uwe Gritzan

Ernst Weber

Sandra Berndt

Mark Trautwein

Christian Votsmeier

Nikolaus Pawlowski

Oliver Von Ahsen

Katharina Filarsky

Sabine Hoff

Philipp Ellinger

Matyas Gorjanacz

Patrick Jones

Helge Roider

Wiebke Maria Nadler

Su-Yi Tseng

Christian Bertling

Pascale Buchmann

Phaik Lyn Oh

The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human,and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Methods of treatment using CCR8 antibodies

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Hercules, CA, United States of America

Pedro Paz