Oxford Nanopore Technologies Limited

Pedro Miguel Ortiz Bahamon

Andrew John Heron

James Anthony Clarke

Clive Gavin Brown

Jason Robert Hyde

Gurdial Singh Sanghera

Paul Raymond Mackett

Justin Millis

Ken Healy

Mark David Jackson

Ping Xie

Jonathan Edward McKendry

Richard Kenneth John Wiltshire

Ioana Pera

Mark Hyland

Rhodri Rhys Davies

Robert Greasty

An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.

Formation of array of membranes and apparatus therefor

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Oxford, United Kingdom

Pedro Miguel Ortiz Bahamon