Novocure Gmbh

Pedro Michael Cavaleiro Miranda

Yoram Palti

Yoram Wasserman

Zeev Bomzon

Eilon Kirson

Noa Urman

Cornelia Wenger

When electrodes are used to impose an electric field in target tissue within an anatomic volume (e.g., to apply TTFields to treat a tumor), the position of the electrodes can be optimized by generating a 3D map of electrical conductivity or resistivity of the anatomic volume. A location of the target tissue within the anatomic volume is identified, and a dipole is added to the 3D map at a location that corresponds to the target tissue. positions for the electrodes that maximize a potential attributable to the dipole are determined based on the 3D map of electrical conductivity or resistivity and the location of the dipole.

Optimizing positions of electrodes for applying tumor treating fields (TTFields) by adding a dipole to a 3D model

When electrodes are used to impose an electric field in target tissue within an anatomic volume (e.g., to apply TTFields to treat a tumor), the position of the electrodes can be optimized by obtaining electrical conductivity measurements in an anatomic volume and generating a 3D map of the conductivity directly from the obtained electrical conductivity or resistivity measurements, without segmenting the anatomic volume into tissue types. A location of the target tissue is identified within the anatomic volume, and the positions for the electrodes are determined based on the 3D map of electrical conductivity and the position of the target tissue.

TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements

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Lisbon, Portugal

Pedro Michael Cavaleiro Miranda