Aktiebolaget Hassle

Ab Hassle

Peder Bernhard Berntsson

Stig Ake Carlsson

Lars Ek

Sven Erik Sjostrand

Gert Christer Strandlund

Enar Ingemar Carlsson

Arne Elof Brandstrom

Bengt Arne Ablad

Benny Roger Samuelsson

Ulf Krister Junggren

Lars Erik Garberg

Gunhild Wika Von Wittken Sundell

Arne E Brandstrom

Enar I Carlsson

Gert C Strandlund

Sven E Sjostrand

Bengt A Ablad

Jan O Gaarder

Bengt R Ljung

Sven Erik Sjastrand

Gustav Benny Samuelsson

The present invention relates to new compounds having antihypertensive effect, which compounds are of the formula I, ##STR1## wherein R.sup.1 is selected from the group consisting of --CH.sub.3, --C.sub.2 H.sub.5, --CH.sub.2 CH.sub.2 OCH.sub.3, and --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5, and R.sup.2 is selected from the group consisting of --C.sub.2 H.sub.5, --CH(CH.sub.3).sub.2, --C(CH.sub.3).sub.3, --CH(CH.sub.3)CH.sub.2 OCH.sub.3, C(CH.sub.3).sub.2 CH.sub.2 OCH.sub.3, and --CH.sub.2 C(CH.sub.3).dbd.CH.sub.2, whereby R.sup.1 and R.sup.2 are not the same, R.sup.3 is selected from the group consisting of chloro, and R.sup.4 is selected from the group consisting of chloro, and methyl, a method for lowering the blood pressure in mammals including man using said compounds, and pharmaceutical preparations containing said compounds.

2,6-Dimethyl-4-2,3-disubstituted

Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R.sup.1 is alkyl or hydroxyalkyl, R.sup.2 is alkoxyalkyl or alkylthioalkyl, and R.sup.3 is halogen, alkyl, alkenyl, alkinyl, alkoxymethyl, or alkoxy are disclosed, as are methods for their preparation. Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the .beta.-receptors of the heart making them useful in treating heart diseases in animals including humans.

Phenoxy-hydroxypropylamines, their preparation, and method and

New amines of the formula ##STR1## wherein the radicals R.sup.1, R.sup.2 and R.sup.3 may be any of a variety of groups described below, several methods for preparing them and the use thereof in the treatment of cardiovascular diseases, particularly in blocking cardial and vascular beta-receptors.

Phenoxy propanolamines

Compounds having the structure ##STR1## AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A METHOD OF INHIBITING THE GASTRIC ACID SECRETION BY ADMINISTERING THEM.

Benzimidazole derivatives useful as gastric acid secretion inhibitors

Compounds having the structural formula ##STR1## PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND THE USE THEREOF FOR AFFECTING GASTRIC ACID SECRETION; INTERMEDIATE PRODUCTS HAVING THE STRUCTURAL FORMULA ##STR2## AND METHODS FOR PREPARING THE SAME.

Substituted 2-[pyridylalkylenesulfinyl]-benzimidazoles with gastric acid

Substituted ureido alkylene phenoxy propanolamines

Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R.sup.1 is alkyl or hydroxy alkyl, R.sup.2 is alkoxyalkyl, alkylthioalkyl, alkoxycarbonylaminoalkyl, or alkoxyalkoxy, and R.sup.3 is halogen, alkyl, alkenyl, alkinyl, alkoxymethyl, or alkoxy are disclosed as are methods for their preparations; Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the .beta.-receptors of the heart making them useful in treating heart diseases in animals including humans.

Growing community of inventors

Vastra Frolunda, Sweden

Peder Bernhard Berntsson