Bionumerik Pharmaceuticals, Inc.

Peddaiahgari Seetharamulu

Dhanabalan Murali

Frederick H Hausheer

Kochat Haridas

Dasharatha Gauravaram Reddy

Pavankumar Nv Petluru

Frederick Herman Hausheer

Shijie Yao

Fredrick H Hausheer

Pavankumar Petluru

A pharmaceutical formulation of a taxane antineoplastic agent, particularly paclitaxel or docetaxel or a pharmaceutically acceptable salt thereof, and N-methylpyrrolidin-2-one (NMP). The formulation may include other excipients and/or diluents, and is suitable for administration to patients with cancer.

Pharmaceutical formulations of taxanes

Novel compounds, formulations and methods of treating patients with cancer are provided for in this invention. The compounds are derivatives of camptothecin, and specifically relate to compounds having novel substitutions at the C-7 position of the camptothecin scaffold B-ring. The formula I compounds are highly lipophilic, lactone stable, do not require metabolic activation, and are potent antineoplastic compounds.

Highly lipophilic camptothecin derivatives

This invention describes a novel formulation containing both cis-diammine dichloro platinum and a water soluble disulfide, 2,2'-dithio-bis-ethane sulfonate in the same solution, wherein the presence of the disulfide and the parenteral administration of the formulation reduces the risk of cisplatin induced nephrotoxicity when treating human patients with cancer.

Sterile aqueous parenteral formulations of cis-diammine dichloro platinum

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San Antonio, TX, United States of America

Peddaiahgari Seetharamulu