Orthopeutics, L.p.

Mep Equine Solutions LLC

Pawel Slusarewicz

Thomas P Hedman

Eric W Hauck

David A Puleo

Sharath C Sundararaj

A protein crosslinker delivery device includes a body and a protein crosslinker held in a synthetic or natural biodegradable polymer. The body, a coating on the body, or an attachment to the body can contain the protein crosslinker holding biodegradable polymer. The release rate of the crosslinker and total amount of crosslinker released can be controlled by varying the concentration of the crosslinker and by varying the composition and structural characteristics of the degradable polymer. Surface eroding, bulk eroding and naturally occurring biodegradable polymers can be used in conjunction with a variety of nontoxic or minimally-toxic protein crosslinking agents. The devices can be used to treat mechanically damaged, deformed, and nutritionally deficient connective or soft tissues such as the knee meniscus, the spinal disc, the cornea, ligaments and tendons, the soft palate, and skin.

Crosslinker enhanced repair of connective tissues

Methods are provided to facilitate the detection and enumeration of neutrophils in bodily fluids, including milk. The methods incorporate the fluorescent staining of neutrophils using fluorogenic enzyme substrates, the imaging of fluorescent cells using a digital device, and the electronic counting of the cells.

Method for the rapid and convenient detection and enumeration of neutrophils in biological samples

Method and kits are provided determining the presence or absence of parasitic helminth eggs in environmental samples, particularly fecal samples. The methods incorporate egg capture methods and the use of N-acetyl-D-glucosamine specific ligands for egg detection.

Method for the quantification of parasite eggs in feces

A method of treating snoring and/or OSA in a subject in need of such treatment. The method includes crosslinking proteins of the subject's soft palate tissue or pharynx tissue. The crosslinking can occur by contacting the soft palate or pharynx tissue with a crosslinking reagent. In addition, the crosslinking can occur without heating, contracting or denaturing of the tissue, or any combination thereof.

Tissue crosslinking for treatment of snoring and obstructive sleep apnea

A method of treating a tear in a knee meniscus of a patient. The method includes exposing the torn knee meniscus to a protein crosslinker during surgery to repair the tear. Also provided is a fixation device for the surgical repair of tears of the meniscus of the knee, where the device contains one or more protein crosslinking reagents.

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Lexington, KY, United States of America

Pawel Slusarewicz