Uniwersytet Jagiellonski

Uniwersytet Marii Curie Sklodowskiej

Uniwersytet Rolniczy Im. Hugona Kollataja W Krakowie

Uniwersytet Jagiello Ski

Pawel Moskal

Michal Silarski

Eryk Czerwinski

Marek Palka

Tomasz Uchacz

Kamil Dulski

Aleksander Gajos

Daria Kaminska

Jerzy Smyrski

Bozena Jasinska

Grzegorz Korcyl

Marcin Kajetanowicz

Gabriel Moskal

Andrzej Danel

Bartosz Glowacz

Marcin Zielinski

Anna Wieczorek

Ines Moskal

Daria Kisielewska

A method and a system for a TOF-PET scanner, the TOF-PET scanner including a scintillation chamber and a detection system comprising detection modules that surround the scintillation chamber. The method includes, for each detection module being calibrated, determining distributions of lifetimes of positrons based on differences of the times of registration of annihilation quanta and of the times of registration of the de-excitation quanta assigned to the common events and registered by the module being calibrated; extracting, from the determined distributions of lifetimes of positrons, a distribution of lifetimes of positrons with annihilation by para-positronium; and determining a time delay constant based on the extracted distributions of lifetimes of positrons with annihilation by para-positronium.

System and method for timing calibration of a detection system of a TOF-PET scanner

The invention relates to a method for reconstruction of an image of a morphometric parameter being a ratio of the frequency of annihilation of an electron with a positron to three and two quanta. The device for imaging the interior of the studied object comprises a series of TOF-PET detection modules (), a data acquisition subsystem (), a data selection subsystem () configured so as to record and identify all types of quanta emitted from the studied object after administration of an isotopic marker, the data processing system being characterised in that it allows for reconstructing () and visualising () of a &#x3b4;(x,y,z) image of the ration of two-quantum and three-quantum annihilations without the necessity to measure the deexcitation quanta.

Method for medical imaging in TOF-PET tomography

A Time-of-Flight Positron Emission Tomography (TOF-PET) tomography insert. The insert includes detection modules and photoelectric converters. Each of the photoelectric converters is connected to an electronic signal processing circuit protected by a housing and comprising an electronic signal processing unit and a computer operable to control the electronic signal processing unit and to reconstruct and store images. Each of the detection modules further includes a liquid marker visible in a magnetic resonance image. The insert also includes a liquid marker device visible in the magnetic resonance image. Adjacent detection modules are detachably connected via coupling elements.

Mobile TOF-PET insert

A hybrid tomograph that includes a chamber for examining an object, a TOF-PET tomograph and an MRI tomograph. The MRI tomograph has a magnet for producing a magnetic field and a receiving-transmitting coil. The TOF-PET tomograph has polymer scintillation strips to transmit scintillation photons outside the magnet of the MRI tomograph and outside the chamber of the hybrid TOF-PET/MRI tomograph. The polymer scintillation strips are arranged circumferentially inside the magnetic field produced by the magnet of the MRI tomograph. Photoelectric converters for converting light signals from the polymer scintillation strips to electrical signals are arranged outside the magnet of the MRI tomograph and outside the chamber of the hybrid TOF-PET/MRI tomograph.

Hybrid TOF-PET/MRI tomograph

A method for reconstructing multi-tracer metabolic and morphometric images. The method includes the steps of: (a) receiving a plurality of events from positron annihilation centers obtained during measurements conducted by TOF-PET tomography; (b) reconstructing the time coordinates and the three-dimensional spatial coordinates for the plurality of events; (c) determining a common decay plane for gamma quanta originating from the positron-electron annihilation; (d) transforming the three-dimensional spatial coordinates for the gamma quanta to a two-dimensional frame of reference of the common decay plane; (e) determining the time coordinates and the spatial coordinates of a place of the annihilation in the common decay plane; and (f) transforming the time coordinates and the spatial coordinates of the place of the annihilation in the two-dimensional frame of reference of the common decay plane to three-dimensional spatial coordinates in a detector coordinate system.

Method for reconstructing multi-tracer metabolic and morphometric images and tomography system for multi-tracer metabolic and morphometric imaging

New composition of polymeric scintillator was revealed, which can be used particularly in medical diagnostics especially in productions of CT scanners, PET scanners and SPECT scanners.

Use of 2-(4-styrylphenyl)benzoxazole and plastic scintillator

The present invention is a device and method for the non-invasive detection of hazardous materials in an aquatic environment, wherein the device comprises a sealed housing, in which there is a fast neutron generator () surrounded by &#x3b1; particle detectors (), and gamma quantum detector (), wherein the fast neutron generator () emits neutrons in the direction of the tested object () through the neutron and/or gamma quanta guide (), and the gamma quanta detector records gamma quanta emitted by the nuclei of the tested object () transmitted through neutron and/or gamma quanta guide ().

Device and method for non-invasive detection of hazardous materials in the aquatic environment

A method for determining parameters of reaction of a gamma quantum within a scintillation detector of a PET scanner, wherein the signal measured by the scintillator is transformed in at least one photomultiplier into an electric measured signal. The method comprises obtaining an access to a database () comprising reference standard signals (W) and reaction parameters assigned to the reference standard signals (W); comparing the measured signal (S) to the reference standard signals (W) and selecting the reference standard signal (W) that best fits the measured signal (S); assigning to the measured signal (S) the reaction parameters assigned to the selected best-fitting reference standard signal (W), as parameters of the reaction of the gamma quantum within the scintillation detector () for the measured signal (S); wherein the measured signal (S) and the reference standard signals (W) are represented by points (P) within a generalized measurement space (&#x3a9;p) having a number of dimensions (N measurements) being equal to the total number of measurements performed for that gamma quantum.

Method and a system for determining parameters of reactions of gamma quanta within scintillation detectors of PET scanners

A detector device for determining a position of reaction of gamma quanta, the device comprising: a detection layer comprising: at least one polymeric or inorganic scintillator () for absorbing gamma quanta and for emitting and propagating scintillation photons; and photoelectric converters () for converting light signals of the scintillation photons into electric signals; and at least one additional layer comprising: strips of material () for absorbing the scintillation photons and for emitting and propagating secondary photons; and photoelectric converters () for converting the light signals for the scintillation photons into electric signals.

Detecting device for determining a position of reaction of gamma quanta and a method for determining a position of reaction of a gamma quanta in positron emission tomography

A system for acquisition of tomographic measurement data from measurement signals (S) of positron emission tomography (PET) or single-photon emission computed tomography (SPECT) detectors, the system comprising: a front-end electronic assembly () configured to convert the measurement signals (S) into digital and analog signals (DAS); a measurement electronics assembly () comprising time to digital converter (TDC) modules () configured to determine times (T) of pulses in digital signals (DS). The measurement electronics assembly () comprises: a series (TDCa-TDCd) of TDC modules (), each module comprising a series (TDC-TDC) of TDC circuits (-); a module controller () configured to transmit a clock signal (CLK), input to the module controller () from a system controller (), to each of the TDC circuits (-); wherein each of the TDC circuits (-) is configured to execute measurements in a measurement window delimited by the neighboring edges of the clock signal (CLK) which is common for all TDC circuits (-).

System for acquisition of tomographic measurement data

A tomograph for imaging an interior of an examined object, the tomograph comprising: TOF-PET detection modules configured to register annihilation quanta and deexcitation quanta and a data reconstruction system () configured to reconstruct an ortho-positronium t-p(x,y,z) lifetime image and a probability of production of positronium P(x,y,z) as a function of position in the imaged object, on the basis of a difference (At) between a time of annihilation (t) and a time of emission of a deexcitation quantum (t), wherein the TOF-PET detection modules () comprise scintillators having a time resolution of less than 100 ps.

TOF-PET tomograph and a method of imaging using a TOF-PET tomograph, based on a probability of production and lifetime of a positronium

A hybrid TOF-PET/CT tomograph comprising a detection chamber, gamma radiation detectors, X-ray detectors and a movable X-ray source, wherein the gamma radiation detectors () and the X-ray detectors () surround the detection chamber () around the whole perimeter of the detection chamber (), and wherein the gamma radiation detectors () are located closer to the longitudinal axis () of the detection chamber () than the X-ray detectors (), and wherein the gamma radiation detectors () comprise polymer strips () made of a scintillation material having a density lower than the density of the X-ray radiation detectors ().

Hybrid TOF-PET/CT tomograph comprising polymer strips made of scintillator material

A method for measuring parameters of an analog signal to determine times at which the analog signal (S) crosses predetermined voltage thresholds (V, V, V, V), the method comprising the steps of: splitting the analog signal (S) into a number of interim signals (S, S, S, S), the number of the interim signals corresponding to the number of the preset voltage thresholds (V, V, V, V); providing an FPGA system () comprising differential buffers (A,B,C,D) with outputs connected to a number of sequences (A,B,C,D) of delay elements (), the number of sequences of delay elements corresponding to the number of the preset voltage thresholds (V, V, V, V); inputting, to an input of each differential buffer (A,B,C,D), one interim signal (S, S, S, S) and a reference voltage corresponding to a particular preset voltage threshold (V, V, V, V); reading, by means of vector generators (A,B,C,D), assigned separately to each of the sequences (A,B,C,D) and connected to a common clock signal (CLK), current values of output signals of each of the delay elements () in the particular sequence (A,B,C,D) at the same moment for all vector generators and providing these values as sequence output vectors (W, W, W, W); and determining times at which the analog signal (S) crosses the predetermined voltage thresholds (V, V, V, V) on the basis of the values of the sequence output vectors (W, W, W, W) and the delays introduced by the delay elements ().

Method and a device for measuring parameters of an analog signal

A method for determining parameters of a reaction of a gamma quantum within a scintillator of a PET scanner, comprising transforming a signal measured in the scintillator using at least one converter into an electric measurement signal, wherein the method comprises the steps of: obtaining access to a reference parameters memory () comprising reference signals represented in a time-voltage (Wt-v) coordinate system and in a time-amplitude fraction (Wt-f) coordinate system and having associated reaction parameters; sampling the electric measurement signal (S) measured in the time-voltage (PT-V) coordinate system and in the time-amplitude fraction (Pt-f) coordinate system; comparing results of the sampling (PT-V, PM) of the electric measurement signal (S) with the reference signals (Wt-V, Wt-f) and selecting reference shape parameters so that the reference (W) is best fitted to the results of the sampling (PT-V, PM) of the electric measurement signal (S); and determining the parameters of the reaction of the gamma quantum within the scintillator () for the electric measurement signal (S) based on pre-calibrated functions that determine the values of parameters of signal shape depending on the parameters of the reaction of gamma quantum within the scintillator.

Method for determining parameters of a reaction of a gamma quantum within a scintillator of a PET scanner

A method for calibration of TOF-PET detectors comprising polymeric scintillator strips and photoelectric converters, wherein cosmic radiation is used as a source of radiation, the method comprising the steps of: recording times of reactions of particles of cosmic radiation with the scintillator strips (); determining spectra () of distribution of differences in the times at which pulses are recorded at ends of the scintillator strips () connected to photoelectric converters (); using the determined spectra () to determine timing synchronization constants of the photoelectric converters (), the constants being related to: delays within the electronics; speed of light propagation within the scintillator strip of the detection module; and resolution of the difference in times of the signals recorded at the ends of the module.

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Czulowek, Poland

Pawel Moskal