Mepha Ag

Mepha Ag Dornacherstrasse 114

Pawan Seth

The process results in an adhesive plaster for the transdermal adminstration of pharmaceutical, in particular heat-sensitive, active substances, composed of an adhesive layer, a backing layer, a matrix layer containing the active substances, and a protective layer. The flux of active substance release is controlled by its diffusion from the matrix layer. The latter is produced by the hot melt method, by mixing an ethylene/vinyl acetate copolymer and an involatile, hydrophobic excipient which is miscible with the latter, is compatible with the active substance and is tolerated by the skin, for example isopropyl myristate or a triglyceride, at the melting point of the mixture, and incorporation therein of a solution or dispersion of the active substance in a small amount of the same excipient.

Process for the production of an adhesive plaster

In addition to the active ingredient, the capsules contain a nonionic surfactant consisting of a polyglycol ester or ether having hydrophilic and lipophilic portions, and an organic polymer which is capable of forming a free-flowing composition with the active ingredient and the surfactant. The essential point for the delay in release is the matching of the water-solubility of the active ingredient and the hydrophilic/lipophilic character (HLB value) of the surfactant as follows:

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Oberwil, Switzerland

Pawan Seth