Teva Pharmaceutical Industries Limited

Teva Pharmaceuticals International Gmbh

Assia Chemical Industries Ltd.

Ivax International Gmbh

Plus Chemicals Sa

Teva Czech Industries S.r.o.

Pavel Vraspir

Roman Gabriel

Alexandr Jegorov

Martin Valik

David Lukas

Francesca Scarpitta

Ondrej Simo

Judith Aronhime

Tamas Koltai

Ales Gavenda

Augusto Canavesi

Jirí Faustmann

Tamás Koltai

Jirí Filipcík

Alexandr Martaus

Tomas Holas

Jiri Faustmann

The present disclosure encompasses solid state forms of Ixazomib Citrate and pharmaceutical compositions thereof. Also disclosed are processes for preparation of Ixazomib Citrate.

Solid state forms of Ixazomib Citrate

Solid state forms of ixazomib citrate

Disclosed are salts of obeticholic acid, solid state forms thereof, processes for preparation thereof, and use thereof in the preparation of pharmaceutical compositions or the preparation of a different solid state form of obeticholic acid or salt thereof, and use in methods of treating liver diseases, e.g. primary biliary cirrhosis (PBC) and nonalcoholic steatohepatitis (NASH).

Solid state forms of obeticholic acid salts

The invention relates to solid state forms of Cabazitaxel and processes for preparing the solid state forms. The invention further relates to pharmaceutical compositions and formulations comprising one or more of the solid state forms.

Solid state forms of cabazitaxel and processes for preparation thereof

Process for the preparation of sunitinib malate form I via sunitinib acetate and polymorphs of said intermediate.

Sunitinib and salts thereof and their polymorphs

The invention relates to solid state forms of Cabazitaxel, and processes for preparation, via novel synthetic intermediates, thereof, and formulations comprising one or more of the solid state forms of Cabazitaxel. The present invention further provides pharmaceutical compositions comprising one or more of the solid state forms of Cabazitaxel, and a method of treating hormone-refractory prostate cancer.

The invention provides crystalline forms of isopropyl alcohol solvate of dasatinib, methods for their preparation, and pharmaceutical compositions thereof. 

Polymorphs of dasatinib isopropyl alcohol and process for preparation thereof

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Rymarov, Czechia

Pavel Vraspir