The United States of America, As Represented by the Secretary, Department of Health and Human Services

Pavel Svoboda

Conrad Padraig Quinn

Jan Pohl

Vera A Semenova

Jarad M Schiffer

Shannon Dalton

Regions ofprotective antigen are provided representing epitopes recognized by antibodies in subjects that have acquired immunity toinfection. The recognition of these epitopes correlates with autoimmunity in a subject. Also provided are vaccines that include at least one of these epitopes that when administered to a subject provide improved acquired immunity.

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Regions ofprotective antigen are provided representing sequences recognized by antibodies in subjects that have vaccine induced lethal toxin neutralizing anti-PA IgG responses. The recognition of these PA regions enhances the utility of anti-PA IgG reactivity as an immune correlate of protection against anthrax in a subject and increases predictive probability of survival. Also provided are vaccines that include at least one of these PA regions that when administered to a subject improve the predictive value of vaccine induced anti-PA IgG and TNA responses as immune correlates of protection against inhalation anthrax.

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Atlanta, GA, United States of America

Pavel Svoboda