Synthon B.v.

Synthon IP Inc.

Pavel Slanina

Theodorus H A Peters

Franciscus B G Benneker

Jiri Bartl

Jacobus Maria Lemmens

Frantisek Picha

The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel acetic acid salt thereof, which affords, inter alia, resolution of the isomers and/or by heat conversion.

Process for making risperidone and intermediates therefor

Amlodipine and related analogues thereof are prepared by the following general reaction scheme:Rand Reach independently represent a C-Calkyl group. The process provides for the formation of compounds of formula (1) in good yield and purity. Further, the compounds of formula (1) can be used as calcium channel blockers or as reference standards or reference markers for checking the purity of amlodipine.

Process for making amlodipine, derivatives thereof, and precursors therefor

Process for making amlodipine

A process for making amlodipine maleate comprises reacting amlodipine or an acid addition salt thereof with maleic acid under an acidic environment to form an amlodipine maleate product. The process allows for the formation of amlodipine maleate substantially free from amlodipine aspartate.

Process for making amlodipine maleate

Tosylate salts are useful in purifying 4-(fluorophenyl)-3-carbinol-piperidines from the corresponding des-fluoro impurity. The purified compounds are advantageously used in paroxetine synthesis.

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Lelekovice, Czechia

Pavel Slanina