Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Pavel Kubalec

Barbara Upmeier

Alfred Engel

Alfons Nichtl

Tobias Oelschlaegel

Veit Peter Grunert

Ursula Klause

Rainer Schlecht

Matthias Rothfuss

Ursula Garczarek

Wolfgang Hösel

The disclosure describes a recombinant immunoglobulin heavy chain comprising a sortase conjugation loop, methods for conjugating and/or labeling such recombinant immunoglobulin heavy chains by use of the enzyme sortase and to the conjugates/labeled products obtained via the method.

Recombinant immunoglobulin heavy chains comprising a sortase conjugation loop and conjugates thereof

Methods and system for determination of an anti-&#x3c;therapeutic monoclonal antibody&#x3e; antibody (anti-&#x3c;TmAB&#x3e;AB) in vitro in a sample from a patient treated with a therapeutic monoclonal antibody (TmAB). Also, methods and systems for the determination of antigen specific antibodies of a particular immunoglobulin class and for the identification of a patient who is at risk of developing an adverse drug reaction (ADR) during treatment with a TmAB.

Assay for measurement of antibodies binding to a therapeutic monoclonal antibody

The invention provides a method for grouping measurement data obtained by effecting two or more techniques to provide characterization data characterizing at least one sample with respect to characterizing substances. According to one aspect of the invention, the grouping is effected on the basis of at least one statistical distribution of deviations (&#x394;m/z) of a respective characterizing measurement value. According to another aspect of the invention, the grouping is effected on the basis of at least one collective characteristic of a plurality of respective quantitative measurement values (I).

Method and system for processing multi-dimensional measurement data

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Feldafing, Germany

Pavel Kubalec