Hewlett-packard Development Company, L.P.

Other

Hewlett-packard Company

Samsung Electronics Co., Ltd.

Hewlett Packard Enterprise Development LP

Pavel Kornilovich

Alexander N Govyadinov

Erik D Torniainen

David P Markel

Peter Mardilovich

James William Stasiak

Kevin Francis Peters

Jong-Souk Yeo

Richard Stanley Williams

Vladek P Kasperchik

Yong Qin Chen

Richard W Seaver

Robert Newton Bicknell

Anand Samuel Jebakumar

Viktor Shkolnikov

Michael G Monroe

Diane R Hammerstad

Jeffrey Todd Mabeck

Adam Higgins

John Lahmann

Carson Denison

Oumnia El Fajri

Alexandre M Bratkovski

Philip John Kuekes

David A Champion

Duncan R Stewart

Alejandro Manuel De Pena

Xiao-An Zhang

David Herbert Donovan

Tim R Koch

Jennifer Wu

Brad Benson

Gregg Combs

Mehmet Fatih Yanik

Alexendre M Bratkovski

Shun-Chi Chang

Daniel C Curthoys

Michael W Cumbie

Michael Renne Ty Tan

Paul Kessler Rosenberg

Xiaoqi Zhou

Zhang-Lin Zhou

Randy Hoffman

Silam J Choy

Sriram Ramamoorthi

Paul J Benning

Neal W Meyer

Hilary Ely

Niranjan Thirukkovalur

Michael J Day

Nick McGuinness

Noorashekin Binte Jamil

Eric D Torniainen

Donald Milton Hill

Peiyun Wang

Jinghua Zhao

Sarita Jairam

Erik D Tornianinen

An example microfluidic structure can include a first microfluidic channel segment in a first elevation plane, a second microfluidic channel segment in a second elevation plane, and a transverse microfluidic channel segment connecting the first microfluidic channel segment to the second microfluidic channel segment. An interior pillar can be positioned at the transverse microfluidic channel segment. The interior pillar can have a tapered downstream edge. The tapered downstream edge can be angled in the first or second elevation plane at an acute angle. A fluid cross-sectional area can increase in the fluid flow direction along the tapered downstream edge.

Microfluidic structures with interior pillars

The present disclosure is drawn to inertial pumps. An inertial pump can include a microfluidic channel, a fluid actuator located in the microfluidic channel, and a check valve located in the microfluidic channel. The check valve can include a moveable valve element, a narrowed channel segment located upstream of the moveable valve element, and a blocking element formed in the microfluidic channel downstream of the moveable valve element. The narrowed channel segment can have a width less than a width of the moveable valve element so that the moveable valve element can block fluid flow through the check valve when the moveable valve element is positioned in the narrowed channel segment. The blocking element can be configured such that the blocking element constrains the moveable valve element within the check valve while also allowing fluid flow when the moveable valve element is positioned against the blocking element.

Inertial pumps

An example microfluidic structure can include a first microfluidic channel segment in a first elevation plane, a second microfluidic channel segment in a second elevation plane, and a transverse microfluidic channel segment connecting the first microfluidic channel segment to the second microfluidic channel segment. An angled exterior wall segment can be at the transverse microfluidic channel segment. The angled exterior wall segment can be angled in the first or second elevation plane at an acute angle with respect to a direction of fluid flow through the first or second microfluidic channel segment. A fluid cross-sectional area can increase in the fluid flow direction along the angled exterior wall segment.

Microfluidic structures with angled exterior wall segments

An example microfluidic mixer can include an inlet microfluidic channel portion and a fluid splitting channel portion including an overpass microfluidic channel to receive fluid from a first side of the inlet microfluidic channel portion and an underpass microfluidic channel to receive fluid from a second side of the inlet microfluidic channel portion, where the underpass microfluidic channel extends under the overpass microfluidic channel such that the channels overlap at their respective downstream ends. A fluid recombining channel portion is downstream of the fluid splitting portion and includes an angled recombining surface having an acute angle with respect to a direction of fluid flow, where the angled recombining surface is between the downstream ends of the overpass and underpass microfluidic channels. An outlet microfluidic channel portion is fluidly connected downstream from the fluid recombining channel portion.

Microfluidic mixers

A reversible micro-valve device includes a main channel, a passage comprising an opening in fluid communication with the main channel, and a side chamber to house a volume of trapped gas. The side chamber is communicably attached to the passage to control flow along the main channel. The side chamber is to be larger in volume than the main channel to which the trapped gas expands and includes one of the following two states at a given time: an open state in which the main channel is open and flow proceeds through the main channel, or a closed state in which the trapped gas within the side chamber is to expand within the passage and block the flow in the main channel.

Reversible micro-valve devices

A microfluidic valve may include a first portion of a liquid conduit to contain a fluid, a second portion of the liquid conduit to contain a liquid and a constriction between the first portion and the second portion and across which a capillary meniscus is to form between the fluid and liquid, the constriction comprising an edge along a ceiling of the constriction.

Microfluidic valves

An example self-priming microfluidic structure can include a microfluidic channel including a floor and a ceiling. A channel height is defined as a distance between the floor and the ceiling. A channel height step can be in the floor, or ceiling, or both. The channel height downstream of the channel height step can be greater than the channel height upstream of the channel height step. An interior pillar can be positioned in the microfluidic channel extending from the floor to the ceiling. The interior pillar can include a widening portion at an upstream end of the interior pillar and a tapering portion at a downstream end of the interior pillar. The interior pillar can overlap the channel height step so that the interior pillar is partially upstream of the channel height step and partially downstream of the channel height step.

Self-priming microfluidic structures

A nucleic acid amplifier may include a sample preparation zone, a fluid ejector, an amplification zone and a capillary break between the amplification zone and the fluid ejector.

Nucleic acid amplification

An example system includes an input channel having a first end and a second end to receive particles through the first end, a sensor to categorize particles in the input channel into one of at least two categories, and at least two output channels. Each output channel is coupled to the second end of the input channel to receive particles from the input channel, and each output channel is associated with at least one category of the at least two categories. Each output channel has a corresponding pump operable, based on the categorization of a detected particle in a category associated with a different output channel, to selectively slow, stop, or reverse a flow of particles into the output channel from the input channel.

Particle categorization

An example method includes providing fluid to a chamber. The chamber feeds a first channel terminating at a first droplet ejector and a second channel terminating at a second droplet ejector. The method further includes sequencing ejection of droplets at the first droplet ejector and the second droplet ejector to induce negative pressure to provide a sequenced output flow of the fluid through the first channel to a first target microfluidic network and through the second channel to a second target microfluidic network, and controlling the first and second target microfluidic networks to perform an analytical process with the fluid.

Sequenced droplet ejection to deliver fluids

An immiscible droplet generation system may include a chip, a microfluidic channel integrated into the chip, an input to the microfluidic channel through which the microfluidic channel is to be filled with a first fluid that is to be moved through the microfluidic channel and a droplet generator. The droplet generator is integrated into the chip to generate a droplet of a second fluid, immiscible within the first fluid, and to inject the droplet into the first fluid in the microfluidic channel.

Droplet generator

A microfluidic device may include at least four interconnected microfluidic channels and a set of fluid actuators. The set of fluid actuators may include a fluid actuator asymmetrically located within at least two of the at least four interconnected microfluidic channels. Each of the at least four interconnected microfluidic channels may be activated to a fluid inputting state, a fluid outputting state and a fluid blocking state in response to selective actuation of different combinations of fluid actuators of the set.

Microfluidic device

An example microfluidic device comprises a plurality of fluidic channels and a fluidic multiplexor. The fluidic multiplexor includes a plurality of fluidic micro-valves fluidically coupled to the plurality of fluidic channels, and a plurality of control lines that cross the plurality of fluidic channels proximal to the plurality of fluidic micro-valves.

Microfluidic devices including fluidic multiplexers

A fluidic device may include a vertical fluid dispensing volume having a side outlet, a fluid channel connected to the vertical fluid dispensing volume below the side outlet and a fluid actuator asymmetrically located between ends of the fluid channel to form an inertial pump to vertically pump fluid within the channel to the side outlet.

Inertial pump fluid dispensing

A microfluidic valve may include a first portion of a liquid conduit to contain a gas, a second portion of a liquid conduit to contain a liquid, and a constriction between the first portion and the second portion and across which a capillary meniscus is to form between the gas and the liquid. The microfluidic valve may further include a drop jetting device within the second portion to open the valve by breaking the capillary meniscus across the constriction.

Microfluidic valve

Growing community of inventors

Corvallis, OR, United States of America

Pavel Kornilovich