Council of Scientific & Industrial Research

Pavan Kumar Togapur

Prathama Satyendra Mainkar

Chandrasekhar Srivari

Somesh Sharma

Chada Raji Reddy

Srigiridhar Kotamraju

Subbarao Mohan Venkata Muppidi

Srinu Paladugu

Ashok Kumar Jha

Prem Kumar Arumugam

Subbarao Mohan Muppidi

Sulfonyl hydroxamic acid compounds have the following general formula: Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R, R, R, R, R, and Rare hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives.

Indole (sulfomyl) n-hydroxy benzamide derivatives as selective HDAC inhibitors

The present invention relates to a process for the preparation of (1-alkylindol-3-ylmethyl) benzoic acid derivatives, in particular Zafirlukast and analogs thereof. Further, this process is based on protection group free and C&#x2014;H bond activation strategy involving all step catalytic transformation sequence and comprises the following steps: Sonogashira coupling, indole formation by SpC&#x2014;H activation, reductive hydrogenation and amidation.

Process for the preparation of Zafirlukast and analogs thereof

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Telangana, India

Pavan Kumar Togapur