Idenix Pharmaceuticals, Inc.

Universita Degli Studi Di Cagliari

Paulo LaColla

Jean-Pierre Sommadossi

Marino Artico

A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1', 2&#x2032; or 3&#x2032;-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.

Methods and compositions for treating flaviviruses and pestiviruses

A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1', 2&#x2032; or 3&#x2032;-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.

Methods and compositions for treating hepatitis C virus

A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1&prime;, 2&prime; or 3&prime;-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.

The invention as disclosed herein is a method and composition for the treatment of HIV in humans and other host animals, that includes the administration of an effective HIV treatment amount of a phenylindole as described herein or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable carrier. The compounds of this invention either possess antiviral (i.e., anti-HIV) activity, or are metabolized to a compound that exhibits such activity.

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Cagliari, Italy

Paulo LaColla