Psomagen, Inc.

Paulo Covarrubias

Jessica Richman

Zachary Apte

Daniel Almonacid

Rodrigo Ortiz

Eduardo Morales

Javier Gimpel

Valeria Marquez

Melissa Alegria

Ingrid Araya

Janet Torres

Nicolas Ordenes

Luis Leon

Felipe Melis

Juan Jimenez

Cristian Bravo

Natalia Scioscia

Eduardo Olivares

Felipe Sepulveda

Therapeutic compositions and an associated method for improving a Toll-like receptor (TLR)-related condition, including determining a set of peptide sequences associated with a microorganism-related modulator of a TLR, determining a first set of binding parameters for the set of peptide sequences in relation to the TLR, selecting a target subset of peptide sequences from the set of peptide sequences based on the first set of binding parameters, reengineering the target subset of peptide sequences based on mutating amino acid residues of the target subset of peptide sequences, determining a second set of binding parameters for the reengineered target subset of peptide sequences in relation to the TLR, and identifying a first peptide for use in a therapeutic composition for improving the TLR-related condition, based on the second set of binding parameters for the reengineered target subset of peptide sequences.

Therapeutic and diagnostics compositions targeting toll-like receptors and methods thereof

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San Francisco, CA, United States of America

Paulo Covarrubias