University of Pennsylvania

Advaxis, Inc.

Paulo Cesar Maciag

Yvonne Paterson

Matthew Seavey

Duane Sewell

Anu Wallecha

Vafa Shahabi

Soldano Ferrone

Nicola Mason

The present invention provides recombinantstrains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.

Compositions comprising angiogenic factors and methods of use thereof

The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.

Non-hemolytic LLO fusion proteins and methods of utilizing same

Provided herein are recombinantstrains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into thegenome in an open reading frame with a nucleic acid sequence encoding a PEST-containing polypeptide, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.

Dual delivery system for heterologous antigens

This invention provides compositions and methods for treating and vaccinating against an Her2/neu antigen-expressing tumor and inducing an immune response against dominant and several sub-dominant epitopes of the antigen.

Compositions and methods for prevention of escape mutation in the treatment of HER2/NEU over-expressing tumors

This invention provides compositions and methods for treating and vaccinating against an Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a non-human animal.

Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors

This invention provides recombinant polypeptides comprising a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA), recombinantstrains comprising same, and methods of inducing an anti-HMW-MAA and anti HER-2/neu immune response thus treating and impeding the growth of tumors, comprising administering same.

Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof

This invention provides recombinant polypeptides comprising a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA), recombinantstrains comprising same, and methods of inducing an immune response and treating and impeding the growth of tumors, comprising administering same.

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Princeton, NJ, United States of America

Paulo Cesar Maciag