Other

Proteotech Inc.

Paula Y Choi

Alan D Snow

Gerardo M Castillo

Beth P Nguyen

Lesley Larsen

Stephen D Lorimer

Elizabeth Nguyen

Joel A Cummings

Beth Nguyen

Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin B2 in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus. The isolated and/or synthesized procyanidin B2 is used to treat amyloid disease, such as Alzheimer's disease and Parkinson's disease as well as improve cognitive performance and increase learning and memory in Alzheimer's patients. Pharmaceutical compositions containing the synthesized and/or isolated procyanidin B2 are also disclosed.

Isolation, purification and synthesis of procyanidin B2 and uses thereof

Assay-guided affinity fractionation and reverse phase high pressure liquid chromatography (HPLC) methodology to isolate, test and characterize the most active water-soluble ingredients within Cat's Claw, or. These components appear to account for the majority of the amyloid or A&#x3b2; fibrillogenesis inhibitory activity. Individual fractions and/or compounds as isolated by HPLC are tested in relevant in vitro and/or animal models, and found to consistently demonstrate inhibition of amyloid or A&#x3b2; fibrillogenesis. Related extraction methods are disclosed.

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Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants

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Bellevue, WA, United States of America

Paula Y Choi