Massachusetts Institute of Technology

Samsung Electronics Co., Ltd.

Dana-farber-cancer Institute Inc.

Nanyang Technological University

Paula T Hammond

Sun Hwa Lee

Angela M Belcher

Darrell J Irvine

Kevin C Krogman

Xiangnan Dang

Yang Shao-Horn

Santiago Correa Echavarria

Erik Christopher Dreaden

Robert Samuel Langer

David M Lynn

Young-Gyoon Ryu

Sangbok Ma

Mariya Khiterer

Mariane Bandeira Melo

Hyunjung Yi

Steven A Castleberry

Nicole S Zacharia

Bo Liu

Bee Eng Mary Chan

Gregory C Rutledge

Michael James McDonald

Michael B Yaffe

Betar Gallant

Angela N Koehler

Younggyoon Ryu

Antonio Eric Barberio

Talar Tokatlian

Matthew T Klug

Jifa Qi

Nasim Hyder

Avni A Argun

Sang Bok Ma

Michael Jungho Lee

Zhiyong Poon

Young Hoon Roh

Peter DeMuth

Younjin Min

Mara L Macdonald

Stephen W Morton

Hye Ryung Byon

Seung Woo Lee

Jiahe Li

J Nathan Ashcraft

Jung Ah Lee

Randall M Hill

Yanpu He

Amanda C Engler

Hyung-il Lee

Dean M DeLongchamp

Wade Wang

Hiroaki Tokuhisa

Eduardo Vazquez

Chibueze Vincent Amanchukwu

Wenbin Zhong

Mohiuddin A Quadir

Joelle Payne Straehla

Natalie Boehnke

Brett C Geiger

Noemie-Manuelle Dorval Courchesne

Jong Bum Lee

Maria Khiterer

Yang Shaohorn

A lithium ion conducting protective film produced using a layer-by-layer assembly process. The lithium ion conducting protective film is assembled on a substrate by a sequential exposure of the substrate to a first poly(ethylene oxide) (PEO) layer including a cross-linking silane component on the first side of the substrate, a graphene oxide (GO) layer on the first PEO layer, a second poly(ethylene oxide) (PEO) layer including a cross-linking silane component on the GO layer and a poly(acrylic acid) (PAA) layer on the second PEO layer. The film functions as a lithium ion conducting protective film that isolates the lithium anode from the positive electrochemistry of the cathode in a lithium-air battery, thereby preventing undesirable lithium dendrite growth.

Lithium ion conducting protective film and method of use

SLC46A3 has been identified as a lipid-based nanoparticle-specific biomarker predictive of nanoparticle-cancer cell affinity. SLC46A3 has a strong inverse association with lipid-based nanoparticle uptake across multiple nanoparticle formulations. Tissues with decreased expression levels of SLC46A3 have a greater uptake of lipid-based nanoparticles. The inverse relationship of SLC46A3 expression in tumor tissue and affinity for lipid-based nanoparticles has therapeutic and diagnostic implications, including cancer therapy and diagnosis, and identification of patients most likely to benefit from a lipid-based nanotherapeutic for improved stratification in clinical trials.

Solute carrier family 46 member 3 (SLC46A3) as marker for lipid-based nanoparticle cancer therapy and diagnostics

Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.

Layer-by-layer nanoparticles for cytokine therapy in cancer treatment

A protective layer can be deposited on a surface of an porous polymer separator placing on a Li-metal electrode to protect against adverse electrochemical activity in a battery. The protective layer can be a multilayered structure including graphene oxide.

Multi-layer structures prepared by layer-by-layer assembly

Disclosed herein are conjugated polymers comprising a polymer and an all-trans retinoic acid (ATRA) prodrug covalently bound to the polymer by a hydrolysable linker L or a pharmaceutically acceptable salt thereof, and methods of using same to treat certain disorders. In an embodiment, the conjugated polymer comprises poly (vinyl alcohol) covalently bound to ATRA through an ester linkage.

Nano-fibular nanoparticle polymer-drug conjugate for sustained dermal delivery of retinoids

A lithium ion conducting protective film is produced using a layer-by-layer assembly process. The lithium ion conducting protective film is assembled on a substrate by a sequential exposure of the substrate to a first poly(ethylene oxide) (PEO) layer including a cross-linking silane component on the first side of the substrate, a graphene oxide (GO) layer on the first PEO layer, a second poly(ethylene oxide) (PEO) layer including a cross-linking silane component on the GO layer and a poly(acrylic acid) (PAA) layer on the second PEO layer. The film functions as a lithium ion conducting protective film that isolates the lithium anode from the positive electrochemistry of the cathode in a lithium-air battery, thereby preventing undesirable lithium dendrite growth.

Disclosed herein are polymers containing repeating units of formula (I) or copolymers containing the repeating units of formula (I) and (II), where Rto R, m, n, p, q, x and y are as defined herein. The polymers and copolymers have an antimicrobial effect and may be used therapeutically or in formulations intended for use as detergents.

Antimicrobial poly(alkylated imidazolium) salts

The present disclosure provides a composite material comprising an electrically conductive polymer, such as poly(3,4-ethylenedioxythiophene) (PEDOT) and an ionically conductive polymer, such as poly(ethylene oxide) (PEO). This composite forms a dual conductor for three-dimensional electrodes in electrochemical applications including lithium ion batteries.

Dual electron-ion conductive polymer composite

A conjugated cationic dendrimer comprising end groups conjugated to charge-shielding groups, wherein some charge-shielding groups are chemically linked to active pharmaceutical ingredients.

Dendrimer drug conjugates for sustained intra-articular delivery

The invention relates to methods of improving efficacy and enhancing silencing of target genes using Ago2 protein-dsRNA complex (RNP) of the invention.

Argonaute protein-double stranded RNA complexes and uses related thereto

Systems and methods for coating a particle core with a layer-by-layer film are disclosed.

Stable layer-by-layer coated particles

A dye-sensitized solar cell can include a plurality of a plasmon-forming nanostructures. The plasmon-forming nanostructures can include an oxide core, an inner metallic shell on a surface of the oxide core, and an outer oxide shell on a surface of the inner metallic shell.

Plasmon-enhanced dye-sensitized solar cells

Growing community of inventors

Newton, MA, United States of America

Paula T Hammond