The University of Birmingham

Paula Mendes

Liam Grover

Richard Williams

Alexander Stephenson-Brown

John S Fossey

A stimuli-responsive surface () comprising a substrate () on which is located a switchable molecule () which has a functional moiety () associated therewith, wherein the switchable molecule () has a first equilibrium state (A) in which access to the functional moiety () is inhibited and a second stimulated state (B), in which access to the functional moiety () is permitted.

Stimuli-responsive surfaces

The invention provides a cell binding composition comprising a shear thinning gel wherein the shear thinning gel having attached to it one or more cell selective binding agents, or the shear thinning gel having dispersed therein a plurality of gel beads, the gel beads having attached to them one or more cell selective binding agents. Methods of enriching cells using the compositions and using the cells to treat injury or disease are also provided.

Cell purification and delivery using shear thinning gel

The present invention relates to a method of preparing a molecular sensor that is specific for a target molecule having a saccharide or peptide region. The method comprises using the target molecule as a template and incubating the template with a receptor to form a template-receptor complex. A molecular scaffold is formed on a surface around the template-receptor complex such that the receptor and at least a portion of the template are embedded in the scaffold, and the template is removed to produce a cavity defined by the scaffold, such that the cavity is complementary to at least a portion of the saccharide or peptide region of the target molecule.

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Birmingham, United Kingdom

Paula Mendes