Children's Medical Center Corporation

Harvard College

Paula I Watnick

Jon Clardy

Shugeng Cao

Julie Szu Yu

Szu Yu Liao

Patrick Ymele-Leki

Provided herein are compositions and methods for the treatment of infections resulting from antibiotic-resistant strains of bacteria.

Antibacterial compounds and uses thereof

Some aspects of this disclosure provide engineered exopolysaccharide-associated proteins, engineered bacteria expressing such proteins, and engineered biofilms comprising such proteins. Some aspects of this disclosure provide methods for engineering exopolysaccharide-associated proteins, and for the generation of engineered bacteria and biofilms expressing or comprising such proteins. Some aspects of this disclosure provide compositions and methods useful for the generation of vaccines and the vaccination of subjects, for delivering molecules of interest to a target site, for example, a surface, for purification of molecules of interest, for example, from bioreactors comprising engineered bacteria as provided herein, and for bioremediation applications, such as the cleanup of environmental pollutants.

Biofilm matrix-boosted vaccine

Bacterial biofilm matrix as a platform for protein delivery

Provided herein are pure and isolated natural products and analogs thereof of Formula (I), (II), (III), and (IV), pharmaceutical compositions thereof, and methods of use, for example, for treating a bacterial infection. Further provided are methods useful in identifying an inhibitor of bacterial sugar fermentation in a bacterial strain, such as a compound (inhibitor) of Formula (I), (II), (III), or (IV): or a pharmaceutically acceptable salt thereof.

Natural product antibiotics and analogs thereof

Growing community of inventors

Waban, MA, United States of America

Paula I Watnick