University of Vermont

Lionheart Technologies, Inc.

Paula B Tracy

Kenneth G Mann

Norman R Alpert

David Schneider

Paul G Held

Burton E Sobel

Paul D Hale

The present invention provides a method for the quantification and assessment of platelet activation in whole blood samples and monitoring of antiplatelet pharmacologic agents. The method for quantifying platelet activation includes exposing platelets to a physiological concentration of an agonist that activates some of the platelets, resulting in the formation of at least one binding site on the surface of the activated platelets, and measuring the activated platelets. The present invention provides a method of assessing specific components of platelet activation.

Method for determining platelet reactivity in a whole blood sample

The present invention is directed to immunochemical detection procedures, e.g., using both Western blotting and direct immunoassays, for Factor V/Va and Factor V/Va fragments, which can thus be used; (a) in a predictive manner to evaluate the existence and/or extent of a thrombotic complication; (b) to monitor the efficacy of prophylaxis for a thrombotic condition; and (c) as a means to evaluate potential risk of hemorrhage during thrombolytic therapy.

Immunologic detection of factor V(VA) fragments in hemorrhagic and

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Essex Junction, VT, United States of America

Paula B Tracy