Other

Paul Zupkas

David G Matsuura

Charles R Holdaway

C Lowell Parsons

S Grant Mulholland

Transluminal drug delivery method and device embodiments can include a urethral suppository formulated to prevent or treat diseases of the urethra and surrounding organs, such as interstitial cystitis or urethritis, by enhancing the absorption of a therapeutic agent of the suppository into body tissues without adversely affecting the natural defense mechanisms of these tissues. Adverse effects on the glycosaminoglycan (GAG) barrier can be mitigated or eliminated by the presence of a suitable polysaccharide in the suppository.

Transluminal drug delivery methods and devices

A urethral suppository comprising a non-meltable base member sized to prevent insertion of the base member into the urethra, a non-meltable reinforcement projecting from the base member, and a meltable portion formed around a portion of the reinforcement. The meltable portion tapers along the reinforcement and is shaped for cooperating with the action of the periurethral musculature to retain the suppository within the urethra. A method of delivering one or more therapeutic agents to the female urinary tract, the method involving insertion of the urethral suppository into the urethra. A method for manufacturing a reinforced urethral suppository.

Reinforced urethral suppository

An ultrasound transducer comprises a sheath body constructed from a nonconductive material. The sheath body is configured to be installed over a medical device. A piezoelectric copolymer transducer is held snugly against the medical device by the sheath body when the ultrasound transducer is installed over the medical device. The piezoelectric copolymer transducer transduces incident ultrasound signals into corresponding electric signals. A ground conductor is coupled to a first surface of the piezoelectric copolymer transducer. A signal conductor is coupled to a second surface of the piezoelectric copolymer transducer and conducts the corresponding electric signals to a proximal end of the medical device.

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San Diego, CA, United States of America

Paul Zupkas