Cell Therapeutics, Inc.

Paul Woodson

David J Porubek

Jack W Singer

James A Bianco

J Peter Klein

Gail E Underiner

Anil M Kumar

Glenn C Rice

John E Tulinsky

Stephen J Klaus

Hydroxyl-containing compounds

Disclosed are therapeutic compounds having the formula:

Hydroxyl-containing bicyclic compounds

A new class of xanthine compounds, variously substituted at the 1, 3, 7 and 8 positions, is characterized by an ability to modulate the activity of key enzymes involved in drug metabolism. These compounds generally are useful in affecting drug metabolism and, particularly, in extending the circulating half-life of compounds that are metabolized via P-450-mediated pathways.

Xanthine modulators of metabolism of cellular P-450

There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.

Enantiomerically pure hydroxylated xanthine compounds

Therapeutic compounds containing a monocyclic five- to six- membered

Enatiomerically pure hydroxylated xanthine compounds

Hydroxyl-containing xanthine compounds

Enantiomerically pure hydroxylated xanthine compounds to treat

Treatment of diseases using enantiomerically pure hydroxylated xanthine

There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in treating inflammatory disease.

Enatiomerically pure hydroxylated xanthine compounds to treat

Process for preparing enantiomerically pure xanthine derivatives

Enantiomerically pure hydroxylated xanthine compounds to treat shock

Them is disclosed compounds and pharmaceutical compositions that is R enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in treating the side effects of immunosuppressive agent and interleukin-2 therapy.

There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in treating proliferative vascular disease.

Growing community of inventors

Bothell, WA, United States of America

Paul Woodson