Universite Du Luxembourg

Other

The University of Arizona

Northern Arizona University

The Translational Genomics Research Institute

Luxembourg Institute of Science and Technology

Paul Wilmes

Frederic Zenhausern

Paul S Keim

David Engelthaler

Lance B Price

James M Schupp

Matthew W Barrett

John D Gillece

Pranjul Shah

Marc Pol Mac Giolla Eain

Emilie Muller

Karsten Hiller

Thekla Cordes

Hugo Roume

Cell culture apparatus for emulating gastrointestinal tract conditions and comprising at least two adjacent, microfluidic, cell cultivation channels separated by a permeable or semipermeable membrane, a first channel carrying gastrointestinal tract epithelial cells or tissues and a second channel carrying luminal and preferably mucosal microbiota, and wherein said second channel comprises one or more dwell chambers capable of providing a location for unattached luminal flora to reside away from any direct flow in said second channel, permits modelling of multiple sections of the gastrointestinal tract and control of retention times.

Cell culture apparatus and culture methods using same

Provided herein is a microphysiological system that may be used in various cell culture applications and biological system studies, that facilitates co-culture, monitoring, and study of functional interactions among different types of cellular and biological materials under various environmental conditions. The system is configured for fast assembly and disassembly, thereby minimizing damage or contamination of the biological materials and environmental conditions inside the system. The system comprises a base, a lid, and a plurality of clamps that are connected to the base and the lid. The base has a recess surface for receiving cell culture support layers. The lid has a stepped surface configured to exert a contact force to a top layer of one or more cell culture support layers during use. The clamp involves an engagement mechanism that generates a contact force allowing for sealing of the cell culture support layers in a manner that minimizes leakage of fluids.

Apparatus for reconfiguration of components in a microphysiological system

Methods for the production of lipids and biofuels with a culture ofspp. grown on a medium such as wastewater or sewage sludge are provided. Thespp. may be cultured with additional microorganisms that contribute to the accumulation of lipids from the growth medium such as Zoog!oea spp.,spp.,spp.,spp., ODI genera incertae sedis. Further discloses are transformed organisms comprising genes isolated from, as well as methods and processes for producing lipids, fatty acids, or biofuels in vitro using the protein products of the isolated genes.

Isolated genes and transgenic organisms for producing biofuels

Growing community of inventors

Bettembourg, Luxembourg

Paul Wilmes