Sanofi

Paul Weissensee

Paul S Wright

Haifeng Eishingdrelo

Jidong Cai

Assay methods and systems use enzymatic cleavage resulting from protein-protein interaction to modulate (activate or inactivate) a reporter.

Identifying molecules modulating protein-protein interactions using protease activated reporters

Methods and assays for identifying a compound that modulates a protein-protein interaction between a first and a second protein. The methods and assays require a protease that is attached to the second protein and a split and rearranged reporter activating protein that is attached to the first protein, wherein the reporter activating protein comprises a cleavage site for the protease that is interposed between two portions of the reporter activating protein and wherein the two portions of the reporter activating protein are in a rearranged order.

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Andover, NJ, United States of America

Paul Weissensee