Massachusetts Institute of Technology

University of Illinois

William Marsh Rice University

Paul Walter Barone

Michael S Strano

Jingqing Zhang

Jong-Ho Kim

Jin-Ho Ahn

James Mitchell Tour

Richard E Smalley

Robert H Hauge

Monica Usrey

W Carter Kittrell

Seunghyun Baik

Christopher A Dyke

Daniel A Heller

Thomas P McNicholas

Nigel F Reuel

Hyeonseok Yoon

Kyungsuk Yum

Ardemis Anoush Boghossian

Rene Ortiz-Garcia

Irene Marie Marek, Legal Representative

A composition can include a complex, where the complex includes a photoluminescent nanostructure and a polymer free from selective binding to an analyte, the polymer adsorbed on the photoluminescent nanostructure, and a selective binding site associated with the complex.

Polymer-nanostructure composition for selective molecular recognition

Sensing compositions, sensing element, sensing systems and sensing devices for the detection and/or quantitation of one or more analytes. Compositions comprising carbon nanotubes in which the carbon nanotubes retain their ability to luminesce and in which that luminescence is rendered selectively sensitive to the presence of an analyte. Compositions comprising individually dispersed carbon nanotubes, which are electronically isolated from other carbon nanotubes, yet which are associated with chemical selective species, such as polymers, particularly biological polymers, for example proteins, which can interact selectively with, or more specifically selectivity bind to, an analyte of interest. Chemically selective species bind, preferably non-covalently, to the carbon nanotube and function to provide for analyte selectivity. Chemically selective species include polymers to which one or more chemically selective groups are covalently attached. Chemically selective polymers include, for example, proteins and polysaccharides.

Sensors employing single-walled carbon nanotubes

A composition can include a nanostructure, and a linker associated with the nanostructure, wherein the linker is configured to interact with a capture protein. The nanostructure can include a single-walled carbon nanotube. A plurality of the compositions can be configured in an array.

Nanotube array for optical detection of protein-protein interactions

A composition for sensing an analyte can include a photoluminescent nanostructure complexed to a sensing polymer, where the sensing polymer includes an organic polymer non-covalently bound to the photoluminescent nanostructure and an analyte-binding protein covalently bound to the organic polymer, and where the analyte-binding protein is capable of selectively binding the analyte, and the analyte-binding protein undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte, can include a complex, where the complex includes a photoluminescent nanostructure in an aqueous surfactant dispersion and a boronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte.

Photoluminescent nanostructure-based sensors

Sensing compositions, sensing element, sensing systems and sensing devices for the detection and/or quantitation of one or more analytes, Compositions comprising carbon nanotubes in which the carbon nanotubes retain their ability to luminesce and in which that luminescence is rendered selectively sensitive to the presence of an analyte. Compositions comprising individually dispersed carbon nanotubes, which are electronically isolated from other carbon nanotubes, yet which are associated with chemical selective species, such as polymers, particularly biological polymers, for example proteins, which can interact selectively with, or more specifically selectivity bind to, an analyte of interest. Chemically selective species bind, preferably non-covalently, to the carbon nanotube and function to provide for analyte selectivity. Chemically selective species include polymers to which one or more chemically selective groups are covalently attached. Chemically selective polymers include, for example, proteins and polysaccharides.

Systems and methods related to compositions including hydrogels and photoluminescent nanostructures are described. The compositions can undergo a change in a physical, chemical, dielectric, or other property upon exposure to an altering stimulus. Changes in one or more properties of the hydrogel may impart a change in the photoluminescence of the nanostructures embedded in the hydrogel.

Systems and methods using photoluminescent nanostructure based hydrogels

The present invention is directed toward methods of selectively functionalizing carbon nanotubes of a specific type or range of types, based on their electronic properties, using diazonium chemistry. The present invention is also directed toward methods of separating carbon nanotubes into populations of specific types or range(s) of types via selective functionalization and electrophoresis, and also to the novel compositions generated by such separations.

Methods for selective functionalization and separation of carbon nanotubes

Selective functionalization of carbon nanotubes

Growing community of inventors

Allston, MA, United States of America

Paul Walter Barone