Bracco International Bv

Bracco Research, USA

Paul W Wedeking

Michael F Tweedle

Ramachandran S Ranganathan

Kondareddiar Ramalingam

Adrian D Nunn

Karen E Linder

Thangavel Arunachalam

Natarajan Raju

Ruth Wager

Ruth E Wager

Nataranjan Raju

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &#x3b1;, &#x3b3;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

Metal complexes derivatized with folate for use in diagnostic and therapeutic applications

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &agr;, &ggr;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

Metal complexes derivatized with folate for use in diagnostic and

In accordance with the present invention a novel method and composition for using nonionic contrast media to reduce the risk of clot formation in a diagnostic procedure is disclosed. Novel compositions for such method are also disclosed. The present method comprises employing a triiodinated phenyl contrast agent having a heterocyclic group or a dimeric triiodinated phenyl contrast agent having one or more heterocyclic groups.

Methods and compositions for using non-ionic contrast agents to reduce

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Pennington, NJ, United States of America

Paul W Wedeking