California Institute of Technology

Boyce Thompson Institute for Plant Research

United States of America, As Represented by the Secretary of Agriculture

University of California

Paul W Sternberg

Frank Clemens Schroeder

Andrea Choe

Stephan H Von Reuss

Chiara Daraio

Fatma Kaplan

Animashree Anandkumar

Hans T Alborn

Zongyi Li

John F Brady

Zhengyu Huang

Zhiwei Peng

Xuan Wan

Tingtao Zhou

Maureen M Barr

Peter E A Teal

Arthur S Edison

Raffi V Aroian

Jagan Srinivasan

Peter A Teal

Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.

Anti-infection fluidic channel

The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.

Utility of nematode small molecules

A method of preventing or treating eosinophilic esophagitis (EoE) comprising administering a composition comprising ascr#7 is described.

Ascaroside treatment of eosinophilic esophagitis

The present invention relates to the use of ascr #7 for preventing or treating IL-6 and/or IL-1&#x3b2;-mediated diseases.

Ascaroside treatment of autoimmune and inflammatory diseases

The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a first location, and methods of treating or preventing parasite infection of a plant.

Small molecule compounds that control plant- and insect-pathogenic nematodes

The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a mammal, and methods of treating or preventing parasite infection of a mammal.

Small molecule compounds that control mammal-pathogenic nematodes

The present invention relates to compounds involved in nematode signaling.

Small molecule compounds for the control of nematodes

A pheromonal compound produced byhas been identified as 5R-(3'-O-[&#x3b2;-D-glucosyl]-tetrahydro-3&#x2032;R,5&#x2032;R-dihydroxy-6&#x2032;S-methyl-2H-pyran-2&#x2032;R-yloxy)-2-hexanone. The novel compound, in combination with other ascarosides, elicit a synergistic signaling response from various adult malespp.

Ascarosides as nematode sex pheromones

Nematodes, such asthat express mutant and wild-type orthologs of human genes involved in polycystic kidney diseases (PKDs), are used to study the functions of the proteins encoded by the genes, to screen for other genes involved in the diseases, to identify mutations involved in the diseases, and to screen for drugs that affect PKD. Behaviors controlled by the action of the genes or gene products are identified and used in the assays. Hence an animal model is provided that permits study of the etiology of polycystic kidney disease and provides a tool to identify the genes involved in the disease pathway, and to identify compounds that may be used to treat or alter the disease progression, lessen its severity or ameliorate symptoms. The nematode genes that encode protein products, mutants of the genes, vectors that contain the genes and mutant genes and nematode strains that contain the vectors are also provided.

Polycystic kidney disease gene homologs required for male mating behavior in nematodes and assays based thereon

Nematodes, such as , that express mutant and wild-type orthologs of human genes involved in polycystic kidney diseases (PKDs), are used to study the functions of the proteins encoded by the genes, to screen for other genes involved in the diseases, to identify mutations involved in the diseases, and to screen for drugs that affect PKD. Behaviors controlled by the action of the genes or gene products are identified and used in the assays. Hence an animal model is provided that permits study of the etiology of polycystic kidney disease and provides a tool to identify the genes involved in the disease pathway, and to identify compounds that may be used to treat or alter the disease progression, lessen its severity or ameliorate symptoms. The nematode genes that encode protein products, mutants of the genes, vectors contain the genes and mutant genes and nematode strains that contain the vectors are also provided.

Growing community of inventors

San Marino, CA, United States of America

Paul W Sternberg