California Institute of Technology

The University of British Columbia

Arizona State University

Paul W Rothemund

Ashwin Gopinath

Christopher Thachuk

David G Kirkpatrick

Rishabh Shetty

Rizal Hariadi

According to one embodiment of the present invention, a structure includes: a substrate having a patterned surface of one or more binding sites; and a molecular shape made by a polynucleotide platform having a shape corresponding to a shape of a binding site of the one or more binding sites, the molecular shape being bound to one of the one or more binding sites.

Method for organizing individual molecules on a patterned substrate and structures assembled thereby

Embodiments of the present disclosure relate generally to single molecule arrays. More particularly, the present disclosure provides materials and methods for generating single molecule arrays using bottom-up self-assembly processes. Materials and methods of the present disclosure can be used to generate single molecule arrays with nanoapertures (e.g., zero mode waveguides) and for carrying out rapid, point-of-care biomolecule detection and quantification.

Materials and methods relating to single molecule arrays

This invention discloses a novel method for constructing a Universal DNA based molecular Turing machine. Included in the invention is a method of operating the DNA based Turing machine of this invention.

Method for construction universal DNA based molecular turing machine

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Pasadena, CA, United States of America

Paul W Rothemund