G.d. Searle & Company

Paul W Manley

Roderick A Porter

Peter J Fellner

Lai M Fook

George J Ellames

Christopher D Floyd

Brendan J Hamill

Mun F Lai

This invention relates to novel imidazopyridine derivatives useful in the treatment of disease or disorders mediated by platelet-activating factor. This invention further relates to pharmaceutical compositions of such imidazopyridine derivatives.

Imidazopyridine derivatives

This disclosure relates to a class of novel substituted alkylidene imidazole derivatives and pharmaceutically acceptable salts thereof. The disclosure further describes pharmaceutical compositions containing such compounds and to the use of such compounds and compositions as agents for selectively inhibiting the action of the enzyme thromboxane synthetase.

Substituted alkylidene imidazoles

This invention relates to novel imidazopyridine derivatives useful in the treatment of diseases or disorders mediated by platelet-activating factor. This invention further relates to pharmaceutical compositions of such imidazopyridine derivatives.

Imidazopyridine derivatives and pharmaceutical compositions

Compounds of the general formula ##STR1## and pharmaceutically acceptable salts thereof have antithrombotic activity. Het represents 1-[1H-imidazolyl], 1-N-morpholinyl or pyridyl. A representative compound is 6-[2-(1H-Imidazol-1-yl)-1-yl-1-[[(4-methoxyphenyl)methoxy]methyl]ethoxy]he xanoic acid.

Heterocyclic group-containing compounds

This invention relates to novel 6-(imidazolylphenyl)-4-iminopyrimidinone compounds having antihypertensive and platelet aggregation inhibition activity. More particularly, the present invention relates to a novel class of pyrimidinone derivatives represented by the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein X may be one to three substituents selected from the group consisting of R,--OR,--SR,--NHR,--NR.sub.2, Cl, Br, F, NO.sub.2,--COCH.sub.3, --COOH,--COOR,--CONHR,--CONR.sub.2, and --OH; and where R represents lower alkyl having 1-6 carbon atoms.

6-(imidazolyphenyl)-4-iminopyrimidinones useful as hypotensive agents

Certain 1H-imidazol-1-yl-1-lower-alkanoic acid derivatives having

Compounds of the general formulae: ##STR1## in which Ar and Ar.sup.1 which may be the same or different represent aromatic radicals optionally substituted once or more than by substituents selected from halogen, lower alkyl and lower alkoxy and Alk represents an alkylene group containing from 1 to 4 carbon atoms which alkylene group may be interrupted with a heteroatom; and acid addition salts thereof. These compounds have anti-anaerobe and also anti-fungal activity and are non-mutagenic.

Imidazole hydrazone and hydrazine derivatives

Compounds corresponding to the following general formula: ##STR1## wherein Ar and Ar.sup.1, which may be the same or different, each represents an aromatic radical which may be substituted one or more times by halogen and/or nitro and/or lower alkyl and/or trihalomethyl and/or cyano and/or lower alkoxy and/or di-lower alkyl-amino, the alkyl groups optionally completing a ring optionally incorporating a further heteroatom, and/or lower alkyl sulphonyl;

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Monks Risborough, United Kingdom

Paul W Manley