Oscient Pharmaceuticals Corporation

Genome Therapeutics Corporation

Paul Van Eerdewegh

Jason Samuel Simon

Randall D Little

Kristina Allen

Tim Keith

Sunil D Pandit

Richard Giulio Del Mastro

Josée Dupuis

Josèe Dupuis

Richard Del Mastro

Jos&egrave;e Dupuis

Jos&eacute;e Dupuis

This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.

Nucleotide and amino acid sequences relating to respiratory diseases and obesity

This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

Human genes relating to respiratory diseases and obesity

This invention relates to isolated nucleic acids comprising genes of human chromosome 20p13-p12 and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

Human gene relating to respiratory diseases and obesity

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Weston, MA, United States of America

Paul Van Eerdewegh